Yuan Xin, Yang Yingxu, Xia Danhao, Meng Lanxia, He Mingyang, Liu Chaoyang, Zhang Zhentao
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Hubei Provincial Institute for Food Supervision and Test, Wuhan, China.
Front Neurosci. 2022 Jan 13;15:807988. doi: 10.3389/fnins.2021.807988. eCollection 2021.
Silica nanoparticles (SiO NPs) are increasingly investigated for their potential in drug delivery systems. However, the neurotoxicity of SiO NPs remains to be fully clarified. Previously SiO NPs have been reported to be detected in the central nervous system, especially in the dopaminergic neurons which are deeply involved in Parkinson's disease (PD). In this article, we characterized the effects of SiO NPs on inducing PD-like pathology both and . Results showed that SiO NPs promote more severe hyperphosphorylation and aggregation of α-synuclein, mitochondria impairment, oxidative stress, autophagy dysfunction, and neuronal apoptosis in the α-Syn A53T transgenic mice intranasally administrated with SiO NPs compared with the control group. Our findings provide new evidence supporting that SiO NPs exposure might have a strong capability of promoting the initiation and development of PD.
二氧化硅纳米颗粒（SiO NPs）因其在药物递送系统中的潜力而受到越来越多的研究。然而，SiO NPs的神经毒性仍有待充分阐明。此前有报道称，在中枢神经系统中检测到了SiO NPs，尤其是在与帕金森病（PD）密切相关的多巴胺能神经元中。在本文中，我们表征了SiO NPs对诱导PD样病理的影响。结果表明，与对照组相比，经鼻给予SiO NPs的α-Syn A53T转基因小鼠中，SiO NPs促进了α-突触核蛋白更严重的过度磷酸化和聚集、线粒体损伤、氧化应激、自噬功能障碍和神经元凋亡。我们的研究结果提供了新的证据，支持暴露于SiO NPs可能具有促进PD发生和发展的强大能力。
