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非金属纳米颗粒对中枢神经系统的不良影响

Adverse Effects of Non-Metallic Nanoparticles in the Central Nervous System.

作者信息

Sikorska Katarzyna, Sawicki Krzysztof, Czajka Magdalena, Kapka-Skrzypczak Lucyna, Kruszewski Marcin, Brzóska Kamil

机构信息

Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.

Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland.

出版信息

Materials (Basel). 2023 Nov 21;16(23):7264. doi: 10.3390/ma16237264.

DOI:10.3390/ma16237264
PMID:38068008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10707257/
Abstract

The interest in nanoparticles (NPs) and their effects on living organisms has been continuously growing in the last decades. A special interest is focused on the effects of NPs on the central nervous system (CNS), which seems to be the most vulnerable to their adverse effects. Non-metallic NPs seem to be less toxic than metallic ones; thus, the application of non-metallic NPs in medicine and industry is growing very fast. Hence, a closer look at the impact of non-metallic NPs on neural tissue is necessary, especially in the context of the increasing prevalence of neurodegenerative diseases. In this review, we summarize the current knowledge of the in vitro and in vivo neurotoxicity of non-metallic NPs, as well as the mechanisms associated with negative or positive effects of non-metallic NPs on the CNS.

摘要

在过去几十年中，人们对纳米颗粒（NPs）及其对生物体的影响的兴趣一直在持续增长。特别关注的是纳米颗粒对中枢神经系统（CNS）的影响，中枢神经系统似乎最易受到其不良影响。非金属纳米颗粒的毒性似乎比金属纳米颗粒小；因此，非金属纳米颗粒在医学和工业中的应用正在迅速增长。因此，有必要更深入地研究非金属纳米颗粒对神经组织的影响，尤其是在神经退行性疾病患病率不断上升的背景下。在这篇综述中，我们总结了目前关于非金属纳米颗粒体外和体内神经毒性的知识，以及与非金属纳米颗粒对中枢神经系统的负面或正面影响相关的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f5d/10707257/979c8f46efd7/materials-16-07264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f5d/10707257/da72367eab5a/materials-16-07264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f5d/10707257/b2f7dac34757/materials-16-07264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f5d/10707257/979c8f46efd7/materials-16-07264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f5d/10707257/da72367eab5a/materials-16-07264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f5d/10707257/b2f7dac34757/materials-16-07264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f5d/10707257/979c8f46efd7/materials-16-07264-g003.jpg

相似文献

[1]
Adverse Effects of Non-Metallic Nanoparticles in the Central Nervous System.

Materials (Basel). 2023-11-21

[2]
Involvement of Programmed Cell Death in Neurotoxicity of Metallic Nanoparticles: Recent Advances and Future Perspectives.

Nanoscale Res Lett. 2016-12

[3]
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[4]
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Environ Geochem Health. 2023-7

[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Differential lncRNA Expression in Undifferentiated and Differentiated LUHMES Cells Following Co-Exposure to Silver Nanoparticles and Nanoplastic.

Materials (Basel). 2025-6-7

[2]
Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications.

Int J Mol Sci. 2024-12-11

本文引用的文献

[1]
Advances and Opportunities in Nanoparticle Drug Delivery for Central Nervous System Disorders: A Review of Current Advances.

Cureus. 2023-8-29

[2]
Cell membrane-based nanomaterials for theranostics of central nervous system diseases.

J Nanobiotechnology. 2023-8-19

[3]
Insights into nanoparticles-induced neurotoxicity and cope up strategies.

Front Neurosci. 2023-5-4

[4]
Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp ().

Front Mol Neurosci. 2022-10-20

[5]
Biopolymer Nanoparticles for Nose-to-Brain Drug Delivery: A New Promising Approach for the Treatment of Neurological Diseases.

J Funct Biomater. 2022-8-24

[6]
Central nervous system injury meets nanoceria: opportunities and challenges.

Regen Biomater. 2022-6-2

[7]
Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route.

Environ Sci Technol. 2022-6-21

[8]
An Insight to Brain Targeting Utilizing Polymeric Nanoparticles: Effective Treatment Modalities for Neurological Disorders and Brain Tumor.

Front Bioeng Biotechnol. 2022-2-3

[9]
Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson's Disease Pathology.

Front Neurosci. 2022-1-13

[10]
Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain.

Nano Lett. 2022-2-9

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