Duan Cong
China Institute of Veterinary Drug Control, Beijing, China.
Front Vet Sci. 2022 Jan 13;8:811187. doi: 10.3389/fvets.2021.811187. eCollection 2021.
The recent experience with SARS-COV-2 has raised our alarm about the cross-species transmissibility of coronaviruses and the emergence of new coronaviruses. Knowledge of this family of viruses needs to be constantly updated. Porcine (PDCoV), a newly emerging member of the genus in the family , is a swine enteropathogen that causes diarrhea in pigs and may lead to death in severe cases. Since PDCoV diarrhea first broke out in the United States in early 2014, PDCoV has been detected in many countries, such as South Korea, Japan and China. More importantly, PDCoV can also infect species other than pigs, and infections have even been reported in children, highlighting its potential for cross-species transmission. A thorough and systematic knowledge of the epidemiology and pathogenesis of PDCoV will not only help us control PDCoV infection, but also enable us to discover the common cellular pathways and key factors of coronaviruses. In this review, we summarize the current knowledge on the prevalence, pathogenicity and infection dynamics, pathogenesis and immune evasion strategies of PDCoV. The existing anti-PDCoV strategies and corresponding mechanisms of PDCoV infection are also introduced, aiming to provide suggestions for the prevention and treatment of PDCoV and zoonotic diseases.
近期感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的经历敲响了我们对冠状病毒跨物种传播性以及新型冠状病毒出现的警钟。对这类病毒的认识需要不断更新。猪德尔塔冠状病毒（PDCoV）是冠状病毒科δ冠状病毒属的一个新出现成员，是一种猪肠道病原体，可导致猪腹泻，严重时可能致死。自2014年初美国首次爆发PDCoV腹泻以来，在韩国、日本和中国等许多国家都检测到了PDCoV。更重要的是，PDCoV还能感染猪以外的物种，甚至有儿童感染的报道，凸显了其跨物种传播的可能性。全面系统地了解PDCoV的流行病学和发病机制，不仅有助于我们控制PDCoV感染，还能使我们发现冠状病毒共同的细胞途径和关键因素。在这篇综述中，我们总结了目前关于PDCoV的流行情况、致病性、感染动态、发病机制和免疫逃逸策略的知识。还介绍了现有的抗PDCoV策略以及PDCoV感染的相应机制，旨在为PDCoV及人畜共患病的预防和治疗提供建议。
