Imataka K, Takahashi N, Seki A, Fujii J
Jpn Circ J. 1982 Apr;46(4):362-8. doi: 10.1253/jcj.46.362.
The present paper describes peculiar lesions in papillary muscles and mitral valves produced by vagal manipulations. In the 109 rabbits killed one week after clipping or crushing of their cervical vagi, papillary muscle and mitral valve lesions were found in 53 (48.6%) and 52 (47.7%) hearts respectively. The lesions were identified by visible deposits of colloidal carbon which had been injected intravenously during the first 3 postoperative days. The left ventricular free wall, interventricular septum and right ventricle were free of carbon deposits. The papillary muscles involved were characterized by swelling and increased stiffness which corresponded to degeneration of the myocardial cells and interstitial fibrosis on microscopic observation. Hydroxyproline content of the papillary muscles involved was 1.4 times more than that of normal hearts, while there was no significant difference in hydroxyproline content of either interventricular septum or left ventricular free wall between the manipulated and the normal preparations. Heart murmurs were heard in 23 animals studied. Phonocardiograms revealed mid to late systolic murmurs with or without midsystolic click. These results indicate that the vagus nerve plays an important role in the pathogenesis of some forms of papillary muscle and mitral valve lesions.
本文描述了迷走神经操作引起的乳头肌和二尖瓣的特殊病变。在对109只家兔的颈迷走神经进行夹闭或挤压一周后处死，分别在53只（48.6%）心脏中发现乳头肌病变，52只（47.7%）心脏中发现二尖瓣病变。这些病变通过术后前3天静脉注射的胶体碳的可见沉积来识别。左心室游离壁、室间隔和右心室均无碳沉积。受累的乳头肌表现为肿胀和硬度增加，显微镜观察显示这与心肌细胞变性和间质纤维化相对应。受累乳头肌的羟脯氨酸含量比正常心脏高1.4倍，而在操作组和正常组的室间隔或左心室游离壁的羟脯氨酸含量方面没有显著差异。在研究的23只动物中听到了心脏杂音。心音图显示收缩中期至晚期杂音，伴有或不伴有收缩中期喀喇音。这些结果表明，迷走神经在某些形式的乳头肌和二尖瓣病变的发病机制中起重要作用。
