Paul Anirudra, Vasseur Camille, Daniel Scott D, Seidel Daniel
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Org Lett. 2022 Feb 11;24(5):1224-1227. doi: 10.1021/acs.orglett.2c00018. Epub 2022 Jan 31.
Relatively unstable cyclic imines, generated in situ from their corresponding alicyclic amines via oxidation of their lithium amides with simple ketone oxidants, engage aryllithium compounds containing a leaving group on an -methylene functionality to provide polycyclic isoindolines in a single operation. The scope of this transformation includes pyrrolidine, piperidine, azepane, azocane, and piperazines.
相对不稳定的环状亚胺,通过用简单的酮氧化剂氧化其锂酰胺,由相应的脂环胺原位生成,与在α-亚甲基官能团上含有离去基团的芳基锂化合物反应,可在一步操作中得到多环异吲哚啉。这种转化的范围包括吡咯烷、哌啶、氮杂环庚烷、氮杂环辛烷和哌嗪。