Ratnam S, March S B
CMAJ. 1986 Jan 1;134(1):43-5, 49.
During a 9-month period in 1984, 113 fecal samples obtained from 92 patients with diarrheal illness were cultured for Escherichia coli serotype O157:H7 to determine the occurrence of this agent in diarrheal illness in Newfoundland. E. coli O157:H7 was isolated in almost pure culture from 12 stool specimens obtained from 7 (15%) of the 47 patients who had grossly bloody diarrhea; none of the 12 yielded any of the usual enteric pathogens. The agent was not isolated from the stool specimens obtained from the remaining 45 patients, who did not have bloody diarrhea. All seven patients whose specimens were positive for E. coli O157:H7 had clinical manifestations typical of hemorrhagic colitis, but the syndrome was clinically suspected and a specific test requested in only two cases. The seven cases were not clustered geographically or temporally, and no common exposure was identified. To determine whether hamburger meat was the source of E. coli O157:H7, 66 samples obtained from various retail outlets were tested; none were found to be positive. Hemorrhagic colitis may be a common disease, and E. coli O157:H7 should be considered as an agent in bloody diarrheal illness.
1984年的9个月期间，从92例腹泻患者采集了113份粪便样本，培养其中的大肠杆菌O157:H7血清型，以确定该病原体在纽芬兰腹泻疾病中的出现情况。从47例有明显血性腹泻的患者中的7例（15%）的12份粪便标本中分离出几乎纯培养的大肠杆菌O157:H7；这12份标本均未检出任何常见肠道病原体。在其余45例无血性腹泻患者的粪便标本中未分离出该病原体。所有7例大肠杆菌O157:H7标本呈阳性的患者均有出血性结肠炎的典型临床表现，但仅2例临床上怀疑有该综合征并进行了特异性检测。这7例病例在地理或时间上没有聚集，也未发现共同暴露源。为确定汉堡肉是否为大肠杆菌O157:H7的来源，对从各零售点采集的66份样本进行了检测；未发现阳性样本。出血性结肠炎可能是一种常见疾病，应将大肠杆菌O157:H7视为血性腹泻疾病的病原体。
