Moorehead R J, Kernohan R M, Patterson C C, McKelvey S T, Parks T G
Dis Colon Rectum. 1986 Jan;29(1):36-8. doi: 10.1007/BF02555285.
A case-control study of 598 patients with colorectal cancer (296 men, 302 women) admitted from January 1974 to October 1983 was undertaken. Patients were matched for age and sex, with controls admitted for unrelated conditions. All information was obtained from the hospital records. In men, there was no evidence of an increased risk of colonic cancer after cholecystectomy relative to men without cholecystectomy. There was some evidence of an increased risk in women (relative risk = 1.7; 95 percent confidence interval, 1.0 to 3.1) and this was highest when the tumor was in the right colon (P less than 0.005). This study confirms previous observations that cholecystectomy leads to an increased risk of right-sided colonic tumors in women but not in men. The apparent difference between the sexes may be explained by the low rate of cholecystectomy in the men examined.
对1974年1月至1983年10月收治的598例结直肠癌患者（296例男性，302例女性）进行了一项病例对照研究。患者按年龄和性别进行匹配，对照组为因无关疾病入院的患者。所有信息均从医院记录中获取。在男性中，相对于未行胆囊切除术的男性，没有证据表明胆囊切除术后患结肠癌的风险增加。有一些证据表明女性患癌风险增加（相对风险=1.7；95%置信区间，1.0至3.1），且当肿瘤位于右半结肠时风险最高（P<0.005）。这项研究证实了之前的观察结果，即胆囊切除术会增加女性患右侧结肠肿瘤的风险，但不会增加男性的风险。两性之间的明显差异可能是由于所检查男性的胆囊切除率较低所致。
