Friedman G D, Goldhaber M K, Quesenberry C P
Lancet. 1987 Apr 18;1(8538):906-8. doi: 10.1016/s0140-6736(87)92871-6.
The records of 5898 patients with colorectal cancer and 27,687 controls were examined for previous cholecystectomy. The estimated relative risks (and 95% confidence intervals) of development of any cancer of the large bowel and cancer of the right colon after cholecystectomy were 1.0 (0.8-1.2) and 1.1 (0.8-1.5) in women and 1.1 (0.9-1.5) and 1.2 (0.8-1.9) in men, respectively. Although these data do not rule out a small increase in risk, it is proposed that the association found in some other studies is, at least in part, an artifact. Intense diagnostic effort and treatment aimed at mild abdominal symptoms, encouraged by some patients and some medical care settings, could increase the detection and removal of gallstones and the early detection of colorectal cancer.
对5898例结直肠癌患者和27687例对照者的记录进行了检查，以了解既往胆囊切除术情况。胆囊切除术后发生任何大肠癌和右半结肠癌的估计相对风险（及95%置信区间）在女性中分别为1.0（0.8 - 1.2）和1.1（0.8 - 1.5），在男性中分别为1.1（0.9 - 1.5）和1.2（0.8 - 1.9）。尽管这些数据不能排除风险有小幅增加，但有人提出，在其他一些研究中发现的关联至少部分是一种假象。在一些患者和一些医疗环境的鼓励下，针对轻微腹部症状进行的强化诊断和治疗，可能会增加胆结石的检测和切除以及结直肠癌的早期发现。
