Toh H
FEBS Lett. 1986 Jan 6;194(2):245-8. doi: 10.1016/0014-5793(86)80093-x.
Recently, the complete nucleotide sequence of the bacteriophage T7 genome was determined and 50 genes were identified on the genome. We compared amino acid sequences of all the gene products of T7 and replication-related gene products of E. coli. As a result, we found that T7 and E. coli share homology for each pair of exonuclease, DNA primase and helix-destabilizing protein. For E. coli, these gene products are known to be involved in the process of discontinuous DNA replication. These observations suggest that T7 and E. coli have a common origin for a part of their replication systems.
最近，噬菌体T7基因组的完整核苷酸序列已被确定，并且在该基因组上鉴定出了50个基因。我们比较了T7所有基因产物的氨基酸序列与大肠杆菌复制相关基因产物的氨基酸序列。结果，我们发现T7和大肠杆菌在核酸外切酶、DNA引发酶和螺旋不稳定蛋白这几对基因产物上具有同源性。对于大肠杆菌而言，已知这些基因产物参与不连续DNA复制过程。这些观察结果表明，T7和大肠杆菌在其复制系统的一部分上具有共同起源。
