Smith P H, Leone J P, Stearns S B
Diabetes. 1986 Jan;35(1):106-9. doi: 10.2337/diab.35.1.106.
Immunocytochemical and radioimmunoassay studies were performed on pancreatic and parotid tissues from diabetic BB and control Wistar rats. Compared with those of normoglycemic controls, the pancreata of diabetic BB rats generally lacked insulin-containing B-cells. Extracts from the parotid glands of diabetic rats contained less immunoassayable insulin-like material than was present in parotid extracts of controls. However, the parotid glands of both groups of animals contained numerous cells displaying insulin-like immunoreactivity. These insulin-immunoreactive cells, located mainly in the intercalated portion of the duct system, were comparable to those we reported recently in the parotid glands of normal and streptozocin-diabetic Sprague-Dawley rats. The presence of an insulin-like material in the parotid salivary gland of two types of diabetic animals suggests that such cells may be spared, in part, from the effects of both chemical and hereditary diabetogenic factors.
对糖尿病BB大鼠和对照Wistar大鼠的胰腺和腮腺组织进行了免疫细胞化学和放射免疫分析研究。与正常血糖对照组相比，糖尿病BB大鼠的胰腺普遍缺乏含胰岛素的B细胞。糖尿病大鼠腮腺提取物中可通过免疫分析检测到的胰岛素样物质比对照组腮腺提取物中的少。然而，两组动物的腮腺中都含有大量显示胰岛素样免疫反应性的细胞。这些胰岛素免疫反应性细胞主要位于导管系统的闰管部分，与我们最近在正常和链脲佐菌素诱导的糖尿病Sprague-Dawley大鼠腮腺中报道的细胞相似。两种糖尿病动物的腮腺唾液腺中存在胰岛素样物质，这表明这些细胞可能在一定程度上免受化学和遗传性致糖尿病因素的影响。
