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碳化钙在食品和水果催熟中的应用:对人类潜在的毒性机制和未来前景。

The use of calcium carbide in food and fruit ripening: Potential mechanisms of toxicity to humans and future prospects.

机构信息

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria; Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria; Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University, 212013, PR China.

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria.

出版信息

Toxicology. 2022 Feb 28;468:153112. doi: 10.1016/j.tox.2022.153112. Epub 2022 Jan 29.

Abstract

The global increase in the demand for ripe fruits has induced unhealthy use of toxic chemicals in fruit ripening. One of such chemicals in common use is calcium carbide (CaC). Due to its nature, commercial CaC is consistently found to contain impurities such as Arsenic and other toxic and carcinogenic chemicals. Few studies have only reported acute associative effects of CaC, whereas there is only sparse evidence of its chronic and long-term impact. This article reviewed all the information on the nature of commercial CaC used for food processing. Meanwhile, all reports on the acute effects of CaC, such as skin burns, skin irritations and inflammation, were summarized. Despite reported acute cases, an increase in commercial CaC for fruit ripening has been reported in recent times, especially in developing countries, as many vendors may consider the toxic effects/risks as negligible. Therefore, this study highlighted the paucity in research studies on the chronic impact of commercial CaC while proposing possible mechanisms for CaC induction of cancer, cardiovascular dysfunction, diabetic mellitus and others. Furthermore, suggestions on further studies to unravel the chronic impacts of CaC on health and recommendations for viable alternatives of fruit ripening with minimal or zero toxicity were proffered. Finally, other suggestions such as improving CaC detection technologies and innovative grassroots educational programs will strengthen national and international agencies to enforce restrictions on the illicit use of the toxicant for fruit ripening.

摘要

全球对成熟水果的需求增加,导致人们在水果催熟过程中不恰当地使用有毒化学品。其中一种常用的化学品是碳化钙(CaC)。由于其性质,商业用碳化钙中总是会发现含有杂质,如砷和其他有毒和致癌的化学物质。很少有研究只报告了 CaC 的急性关联效应,而对其慢性和长期影响的证据很少。本文综述了用于食品加工的商业碳化钙的性质的所有信息。同时,还总结了所有关于 CaC 的急性效应的报告,如皮肤烧伤、皮肤刺激和炎症。尽管有报告称发生了急性病例,但最近,特别是在发展中国家,用于水果催熟的商业碳化钙的用量有所增加,因为许多供应商可能认为有毒效应/风险可以忽略不计。因此,本研究强调了对商业碳化钙慢性影响的研究不足,并提出了 CaC 诱导癌症、心血管功能障碍、糖尿病等的可能机制。此外,还就进一步研究以揭示 CaC 对健康的慢性影响提出了建议,并提出了使用毒性最小或零的替代物进行水果催熟的可行建议。最后,提出了其他建议,如改进 CaC 检测技术和创新的基层教育计划,以加强国家和国际机构对非法使用该毒物进行水果催熟的限制。

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