Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pathol Res Pract. 2022 Mar;231:153780. doi: 10.1016/j.prp.2022.153780. Epub 2022 Jan 25.
miR-145-5p is a microRNA whose role in diverse disorders has been verified. This miRNA is encoded by MIR145 gene on chromosome 5. This miRNA is mainly considered as a tumor suppressor miRNA in diverse types of cancers, including bladder cancer, breast cancer, cervical cancer, cholangiocarcinoma, renal cancer, and gastrointestinal cancers. However, few studies have reported up-regulation of this miRNA in some cancers. Moreover, it has been shown to affect pathogenesis of a number of non-malignant conditions such as aplastic anemia, asthma, cerebral ischemia/reperfusion injury, diabetic nephropathy, rheumatoid arthritis and Sjögren syndrome. In the current review, we summarize the available literature about the role of miR-145-5p in these conditions.
miR-145-5p 是一种 microRNA，其在多种疾病中的作用已得到验证。该 miRNA 由染色体 5 上的 MIR145 基因编码。这种 miRNA 主要被认为是多种癌症（包括膀胱癌、乳腺癌、宫颈癌、胆管癌、肾癌和胃肠道癌）中的肿瘤抑制 miRNA。然而，很少有研究报道在一些癌症中该 miRNA 的上调。此外，它已被证明会影响许多非恶性疾病的发病机制，如再生障碍性贫血、哮喘、脑缺血/再灌注损伤、糖尿病肾病、类风湿关节炎和干燥综合征。在本综述中，我们总结了关于 miR-145-5p 在这些疾病中的作用的现有文献。
