酿酒酵母天冬酰胺酶II：导致去阻遏酶合成的四个突变的筛选。
Asparaginase II of Saccharomyces cerevisiae: selection of four mutations that cause derepressed enzyme synthesis.
作者信息
Kamerud J Q, Roon R J
出版信息
J Bacteriol. 1986 Jan;165(1):293-6. doi: 10.1128/jb.165.1.293-296.1986.
Abstract
A positive selection method was used to isolate four Saccharomyces cerevisiae mutations that cause derepressed synthesis of asparaginase II. The four mutations (and1, and2, and3, and4) were neither closely linked to each other nor linked to previously characterized mutations (asp3, asp6) which cause the complete loss of asparaginase II activity. One of the new mutations (and4) was shown to be allelic to gdh-CR, a pleiotropic mutation which causes derepressed synthesis of a number of enzymes of nitrogen catabolism.
摘要
采用正向选择法分离出四个导致天冬酰胺酶II合成去阻遏的酿酒酵母突变体。这四个突变体（and1、and2、and3、and4）彼此之间既不紧密连锁，也不与先前鉴定的导致天冬酰胺酶II活性完全丧失的突变体（asp3、asp6）连锁。其中一个新突变体（and4）被证明与gdh-CR等位，gdh-CR是一个多效性突变体，可导致多种氮分解代谢酶的合成去阻遏。
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