Department of Biomedical Sciences, University of Padova, Padova, Italy.
Acta Crystallogr D Struct Biol. 2022 Feb 1;78(Pt 2):144-151. doi: 10.1107/S2059798321012109. Epub 2022 Jan 21.
Intrinsically disordered regions (IDRs) lacking a fixed three-dimensional protein structure are widespread and play a central role in cell regulation. Only a small fraction of IDRs have been functionally characterized, with heterogeneous experimental evidence that is largely buried in the literature. Predictions of IDRs are still difficult to estimate and are poorly characterized. Here, an overview of the publicly available knowledge about IDRs is reported, including manually curated resources, deposition databases and prediction repositories. The types, scopes and availability of the various resources are analyzed, and their complementarity and overlap are highlighted. The volume of information included and the relevance to the field of structural biology are compared.
无固定三维蛋白质结构的无序区域 (IDR) 广泛存在，并在细胞调控中发挥核心作用。只有一小部分 IDR 的功能得到了表征，而大量的异质实验证据在文献中被埋没。IDR 的预测仍然难以估计，并且特征描述也很差。本文报告了关于 IDR 的公开知识概述，包括手动整理的资源、存储库和预测库。分析了各种资源的类型、范围和可用性，并强调了它们的互补性和重叠性。比较了所包含信息的数量和与结构生物学领域的相关性。
