Department of Pediatric and Preventive Dentistry, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
J Indian Soc Pedod Prev Dent. 2021 Oct-Dec;39(4):398-402. doi: 10.4103/jisppd.jisppd_246_21.
Silver diamine fluoride (SDF) is employed as an adjunct cariostatic agent in the management of dental caries in high-risk population. Other than fluorides, chlorhexidine (CHX) is the most potent antimicrobial and efficacious agent against Streptococcus mutans.
The aim of this study is to evaluate and differentiate the efficacy of 38% silver diamine fluoride, CHX varnish, and fluoride varnish on carious primary teeth.
Ninety children having a count of ≥1 carious lesion were recruited. Thirty-eighty percent silver diamine fluoride or fluoride varnish and CHX varnish were topically applied on the lesion. The primary outcome measured was the arrest of carious lesion (lesion rendered inactive as per the Nyvad criteria) after a follow-up of 14-21 days. Dental biofilm sample was obtained from each child and subsequently assessed for microbial composition by colony-forming unit method before and after treatment followed by protein analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis method.
Average proportion of arrested caries lesions in the SDF group was higher followed by CHX and fluoride varnish groups. Decreased total protein amount was found in SDF group. This proves that there is decrease in microbial load posttreatment in SDF group.
Thirty-eight percent SDF is more effective than CHX varnish and fluoride varnish in arresting dentin carious lesions in young children.
银胺氟（SDF）被用作高危人群龋齿管理中的辅助防龋剂。除了氟化物以外，洗必泰（CHX）是针对变形链球菌最有效和最有效的抗菌剂。
本研究旨在评估和区分 38％的银胺氟、CHX 涂料和氟化物涂料对乳牙龋齿的疗效。
招募了 90 名患有≥1 个龋齿病变的儿童。在病变部位局部应用 38％的银胺氟或氟化物涂料和 CHX 涂料。主要观察指标是在 14-21 天的随访后龋齿病变的抑制（根据 Nyvad 标准病变失活）。在治疗前后从每个儿童中获得牙菌斑样本，并通过平板计数法评估微生物组成，然后通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳法分析蛋白质。
SDF 组的平均龋齿病变抑制比例较高，其次是 CHX 组和氟化物涂料组。SDF 组的总蛋白量减少。这证明 SDF 组治疗后微生物负荷减少。
38％的 SDF 比 CHX 涂料和氟化物涂料更有效地抑制儿童牙本质龋齿病变。
