Krob M J, Shelby J
J Trauma. 1986 Jan;26(1):40-3. doi: 10.1097/00005373-198601000-00006.
Burn injuries and blood transfusions both have been implicated as causes of suppressed immune responses. Skin allograft survival in a burned mouse model was studied to determine the relationships among burn injury, blood transfusion, and phlebotomy before transfusion as they affected immunocompetence. At 7 days after 20% TBSA full-thickness burn injury, allograft skin survival was prolonged compared to nonburned control. When increasing volumes of blood were transfused, allograft survival times decreased accordingly. Phlebotomy before transfusion tended to enhance this response. Similar results were seen at 14 days after burn injury, although phlebotomy before transfusion did not further decrease allograft survival time at 14 days. This study demonstrated that blood transfusions were not additively immunosuppressive over burn injury alone. Increased amounts of transfused blood restore allogeneic responsiveness. Phlebotomy may enhance this response when performed early after burn injury.
烧伤和输血都被认为是免疫反应受抑制的原因。研究了烧伤小鼠模型中同种异体皮肤移植的存活情况，以确定烧伤、输血和输血前放血之间的关系，因为它们会影响免疫能力。在20%体表面积全层烧伤后7天，与未烧伤对照组相比，同种异体移植皮肤的存活时间延长。当输注的血量增加时，同种异体移植存活时间相应缩短。输血前放血往往会增强这种反应。在烧伤后14天也观察到了类似结果，尽管输血前放血在14天时并没有进一步缩短同种异体移植存活时间。这项研究表明，输血并非单独烧伤时额外的免疫抑制因素。输注血量增加会恢复同种异体反应性。在烧伤后早期进行放血可能会增强这种反应。
