Shelby J, Krob M J
J Trauma. 1986 Jan;26(1):54-6. doi: 10.1097/00005373-198601000-00010.
Blood transfusions are known to improve allograft survival times, and this effect is enhanced with recipient immunosuppression. The focus of the present study was to determine the effect of pretransplant and perioperative donor-specific (DST) or nonspecific (NST) blood transfusion on skin allograft survival in thermally injured mice. Allogeneic immune responsiveness was suppressed in 20% TBSA burned mice, but not to a degree which was protective against DST-induced sensitization. Pretransplant DST resulted in accelerated graft rejection in burned recipients, although high-dose cyclosporine partially reversed this sensitization. Additionally, burn-related immunosuppression in this model did not enhance perioperative transfusion-induced graft prolongation. However, when burn-injured perioperatively transfused mice were further immunosuppressed with cyclosporine, significant graft prolongation occurred. These data suggest that perioperative NST may contribute to prolonged skin graft survival in burned recipients, provided that the mice are sufficiently immunosuppressed.
已知输血可延长同种异体移植的存活时间，并且在接受者免疫抑制的情况下这种效果会增强。本研究的重点是确定移植前及围手术期供体特异性（DST）或非特异性（NST）输血对热损伤小鼠皮肤同种异体移植存活的影响。20%体表面积烧伤的小鼠的同种异体免疫反应性受到抑制，但程度不足以抵御DST诱导的致敏。移植前的DST导致烧伤受体的移植物排斥加速，尽管高剂量环孢素部分逆转了这种致敏作用。此外，该模型中与烧伤相关的免疫抑制并未增强围手术期输血诱导的移植物延长。然而，当围手术期输血的烧伤小鼠用环孢素进一步免疫抑制时，移植物出现了显著延长。这些数据表明，只要小鼠得到充分的免疫抑制，围手术期的NST可能有助于延长烧伤受体的皮肤移植存活时间。
