Lewis R W, Roberts J A
J Urol. 1986 Jan;135(1):182-4. doi: 10.1016/s0022-5347(17)45558-3.
The purpose of this study was to determine if chronic cystitis interferes with maturation of the ureterovesical junction, thus prolonging vesicoureteral reflux in infant rhesus monkeys (Macaca mulatta). Serial implantations of a Proteus-infested silastic pellet into the bladder wall ensured continued infection as demonstrated by urine culture. Chronic cystitis as evidenced by pathological findings at surgery and sacrifice was created in a group of infant monkeys who had initial spontaneous vesicoureteral reflux. There was no evidence of pyelonephritis. Four animals represent a short term study since they were followed from four months to one year of age. Three animals were long term studies and were evaluated for at least 21/2 years. In no animals did chronic cystitis delay the normal disappearance of vesicoureteral reflux that is commonly seen in these animals as the ureterovesical junction matures, as demonstrated by serial cystograms. In two animals reflux (after initial clearing) reappeared when a bladder calculus formed in these chronically infected animals. Renal damage occurred only in these animals. In conclusion, this animal model failed to demonstrate interference with normal vesicoureteral junction maturation in the face of a chronic bladder infection.
本研究的目的是确定慢性膀胱炎是否会干扰输尿管膀胱连接部的成熟，从而延长恒河猴幼猴（猕猴）的膀胱输尿管反流。如尿液培养所示，将感染变形杆菌的硅橡胶小球连续植入膀胱壁可确保持续感染。在一组最初存在自发性膀胱输尿管反流的幼猴中，通过手术和处死时的病理发现证实了慢性膀胱炎的存在。没有肾盂肾炎的证据。四只动物为短期研究，因为它们从4个月大到1岁一直被跟踪观察。三只动物为长期研究，评估时间至少为2年半。连续膀胱造影显示，在任何动物中，慢性膀胱炎均未延迟输尿管膀胱连接部成熟时这些动物中常见的膀胱输尿管反流的正常消失。在两只动物中，当这些慢性感染动物形成膀胱结石时，反流（在最初清除后）再次出现。仅在这些动物中发生了肾损伤。总之，面对慢性膀胱感染，该动物模型未能证明对正常输尿管膀胱连接部成熟有干扰。
