Miller T E, Lecamwasam J P, Ormrod D J, Findon G, Cornish J
Department of Medicine, Auckland Hospital, New Zealand.
Br J Exp Pathol. 1987 Aug;68(4):575-83.
Chronic cystitis due to Escherichia coli is frequently associated with anatomical or functional abnormalities of the lower urinary tract, but there is no satisfactory animal model available to help resolve biological and management problems. We have induced chronic infection of the unobstructed urinary tract in the rat by implanting a small polyurethane sponge into the dome of the bladder, 14 days before bacterial challenge. This manipulation provides a focus of infected urine and leads to the establishment of a chronic cystitis. Both the predisposing factor and the pathological details mimic important features of the disease in man.
由大肠杆菌引起的慢性膀胱炎常与下尿路的解剖或功能异常相关，但目前尚无令人满意的动物模型来帮助解决生物学和管理方面的问题。我们通过在细菌攻击前14天将一块小的聚氨酯海绵植入大鼠膀胱顶部，诱导大鼠无梗阻尿路发生慢性感染。这种操作提供了一个感染尿液的病灶，并导致慢性膀胱炎的形成。其诱发因素和病理细节都模拟了人类疾病的重要特征。
