Department of Dermatology, Taixing People's Hospital, Jiangsu Taixing 225400, China.
Department of Radiotherapy, Taixing People's Hospital, Jiangsu Taixing 225400, China.
Anal Cell Pathol (Amst). 2022 Jan 22;2022:4220786. doi: 10.1155/2022/4220786. eCollection 2022.
Basal cell carcinoma (BCC) is the most common malignancy worldwide, with increasing incidence. BCCs present low mortality but high morbidity, and its pathogenesis remains unclear. Eph receptors have been implicated in tumorigenesis. EphA7 plays a role as a tumor suppressor in certain cancers. We checked EphA7 expression levels and methylation status in a set of BCCs, benign skin diseases, and compound nevus tissue samples using immunohistochemistry. EphA7 protein was positively expressed in normal basal cells, benign skin diseases, and compound nevus cells, but lost in areas of BCC tissues. We detected hypermethylation in BCC tissue samples with reduced expression of EphA7. There is a significant relationship between the expression level of EphA7 receptor protein and the methylation status of CpG islands in the EphA7 promoter region ( < 0.001). To our knowledge, this is the first study to report the EphA7 expression profile and hypermethylation of EphA7 in BCC. The role of the EphA7 gene and the status of hypermethylation in tumorigenesis and treatment of BCC warrant further investigation.
基底细胞癌（BCC）是全球最常见的恶性肿瘤，发病率呈上升趋势。BCC 的死亡率低，但发病率高，其发病机制尚不清楚。Eph 受体与肿瘤的发生有关。EphA7 在某些癌症中作为肿瘤抑制因子发挥作用。我们使用免疫组织化学方法检查了一组 BCC、良性皮肤病和复合痣组织样本中的 EphA7 表达水平和甲基化状态。EphA7 蛋白在正常基底细胞、良性皮肤病和复合痣细胞中呈阳性表达，但在 BCC 组织区域丢失。我们检测到 EphA7 表达降低的 BCC 组织样本中存在高度甲基化。EphA7 受体蛋白的表达水平与 EphA7 启动子区域 CpG 岛的甲基化状态之间存在显著关系（<0.001）。据我们所知，这是第一项报道 EphA7 在 BCC 中的表达谱和 EphA7 高甲基化的研究。EphA7 基因的作用及其在肿瘤发生和 BCC 治疗中的高甲基化状态值得进一步研究。
