Laboratorio de Inmunología, Unidad de Morfología y Función. Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, México.
Clínica Universitaria de Salud Integral, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, México.
Hum Vaccin Immunother. 2022 Dec 31;18(1):2028514. doi: 10.1080/21645515.2022.2028514. Epub 2022 Feb 1.
Human papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases, and the main etiology of cervical cancer. This study was aimed to assess type-specific cervical HPV prevalence and their association with HPV-specific antibodies in a cohort of female university students. HPV genotyping was performed by amplifying and sequencing a fragment of the L1 protein. A BLAST search was performed to identify HPV types. HPV-specific IgG antibodies were measured by ELISA in serum samples. A total of 129 women participated, with an average age of 21.75 years. The prevalence of vaginal HPV infection was 74.42%. The most predominant high-risk HPV types were 18 (13.95%), 31 (10.85%), and 16 (9.3%). We found that early age at coitarche and a higher number of sexual partners were significantly associated with a high prevalence of HPV infection. In addition to sexual behavior, we observed that the presence of serum-specific IgG antibodies against HPV can impact the prevalence of the virus. Seropositivity to HPV-16 and HPV-18 was associated with a lower prevalence of HPV-16, but not for other HPV types. Of note, there was a lower proportion of HPV-specific seropositivity in women who had the presence of the same HPV type in a cervical specimen, suggesting an immunoregulatory mechanism associated with the viral infection. In conclusion, the prevalence of HPV in university women was higher than expected and it was associated with early age of sexual debut, an increasing number of sexual partners, and a low proportion of HPV seropositivity.
人乳头瘤病毒（HPV）是最常见的性传播疾病之一，也是宫颈癌的主要病因。本研究旨在评估女性大学生人群中特定型别的宫颈 HPV 流行率及其与 HPV 特异性抗体的相关性。HPV 基因分型通过扩增和测序 L1 蛋白片段来完成。通过 BLAST 搜索来识别 HPV 类型。HPV 特异性 IgG 抗体在血清样本中通过 ELISA 进行测量。共有 129 名女性参与，平均年龄为 21.75 岁。阴道 HPV 感染的流行率为 74.42%。最主要的高危 HPV 类型为 18 型（13.95%）、31 型（10.85%）和 16 型（9.3%）。我们发现，初次性交年龄较小和性伴侣数量较多与 HPV 感染的高流行率显著相关。除性行为外，我们还观察到血清中针对 HPV 的特异性 IgG 抗体的存在可能会影响病毒的流行率。HPV-16 和 HPV-18 的血清阳性与 HPV-16 流行率降低相关，但对其他 HPV 类型则没有影响。值得注意的是，在宫颈标本中存在相同 HPV 类型的女性中，HPV 特异性血清阳性的比例较低，这表明存在与病毒感染相关的免疫调节机制。总之，大学生女性 HPV 的流行率高于预期，与初次性交年龄较小、性伴侣数量增加以及 HPV 血清阳性率较低有关。
