Littenberg B, Gluck E H
N Engl J Med. 1986 Jan 16;314(3):150-2. doi: 10.1056/NEJM198601163140304.
Ninety-seven acutely ill patients with bronchial asthma were enrolled in a double-blind, placebo-controlled, randomized trial of intravenous methylprednisolone (125 mg), given on presentation in the emergency room in addition to standard emergency treatments for asthma. Subjective and spirometric indexes of the severity of the asthma were similar on entry into the study in all patients, but only 9 of 48 patients (19 percent) treated with methylprednisolone required hospital admission, as compared with 23 of 49 patients (47 percent) in the control group (P less than 0.003). Our results suggest that prompt use of glucocorticoids in the emergency treatment of severe asthma can prevent significant morbidity, reduce the number of hospitalizations, and effect substantial savings in health care costs.
97例急性支气管哮喘患者参与了一项双盲、安慰剂对照、随机试验，除哮喘标准急救治疗外，在急诊室就诊时静脉注射甲泼尼龙（125mg）。所有患者在进入研究时哮喘严重程度的主观和肺功能指标相似，但接受甲泼尼龙治疗的48例患者中只有9例（19%）需要住院，而对照组49例患者中有23例（47%）需要住院（P<0.003）。我们的结果表明，在严重哮喘的急救中迅速使用糖皮质激素可预防严重发病，减少住院次数，并大幅节省医疗费用。
