Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, H3A 0B8, Canada.
ChemSusChem. 2022 Apr 7;15(7):e202102084. doi: 10.1002/cssc.202102084. Epub 2022 Feb 23.
Mechanoenzymology is an emerging field in which mechanical mixing is used to sustain enzymatic reactions in low-solvent or solvent-free mixtures. Many enzymes have been reported that thrive under such conditions. Considering the central role of biopolymers and synthetic polymers in our society, this minireview highlights the use of mechanoenzymology for the synthesis or depolymerization of oligomeric or polymeric materials. In contrast to traditional in-solution reactions, solvent-free mechanoenzymology has the advantages of avoiding solubility issues, proceeding in a minimal volume, and reducing solvent waste while potentially improving the reaction efficiency and accessing new reactivity. It is expected that this strategy will continue to gain popularity and find more applications.
机械酶学是一个新兴领域，它利用机械混合来维持低溶剂或无溶剂混合物中的酶反应。已经有许多酶被报道在这种条件下茁壮成长。考虑到生物聚合物和合成聚合物在我们社会中的核心作用，本综述强调了机械酶学在低聚物或聚合物材料的合成或解聚中的应用。与传统的溶液反应相比，无溶剂机械酶学具有避免溶解度问题、在最小体积下进行以及减少溶剂浪费的优点，同时还可能提高反应效率并获得新的反应性。预计这种策略将继续受到欢迎并找到更多的应用。
