Rosati G, Aiello I, Granieri E, Pirastru M I, Becciu S, Demontis G, Mannu L, Zoccheddu A
Neurology. 1986 Jan;36(1):14-9. doi: 10.1212/wnl.36.1.14.
Intensive search of all cases of MS occurring in the Sardinian commune of Macomer since 1912 indicated that MS was absent up to the early 1950s. All 13 ascertained cases had clinical onset in the years 1952-1981. During this period, the average annual incidence was 4.8 per 100,000; the highest incidence was found in the period 1957-1961, slowly decreasing up to 1981. MS was probably introduced after 1945, when the centuries-old isolation of Macomer ended and the native population came into contact with individuals from high- and medium-risk areas.
对自1912年以来在撒丁岛马科梅尔镇发生的所有多发性硬化症病例进行的深入调查表明，直到20世纪50年代初都没有多发性硬化症病例。所有确诊的13个病例的临床发病时间都在1952年至1981年之间。在此期间，年平均发病率为每10万人4.8例；最高发病率出现在1957年至1961年期间，到1981年逐渐下降。多发性硬化症可能是在1945年之后传入的，当时马科梅尔镇长达几个世纪的与世隔绝状态结束，当地居民开始与来自高风险和中等风险地区的人接触。
