Weiss M A, Daquioag E, Margolin E G, Pollak V E
Am J Kidney Dis. 1986 Jan;7(1):20-8. doi: 10.1016/s0272-6386(86)80052-x.
Six patients are reported with nephrotic syndrome and relatively rapid progression to irreversible renal failure. The renal histologic findings are unusual. The most striking changes are collapse of glomerular capillary loops, such as might occur with glomerular hypoperfusion; significant tubulointerstitial damage is also seen. These patients appear to have a clinicopathologic entity hitherto unreported. Its differentiation from other causes of progressive glomerular damage, and particularly from focal and segmental glomerulosclerosis, is discussed.
报告了6例肾病综合征患者，其病情进展相对较快，发展为不可逆性肾衰竭。肾脏组织学检查结果异常。最显著的变化是肾小球毛细血管襻塌陷，类似于肾小球灌注不足时可能出现的情况；同时也可见明显的肾小管间质损伤。这些患者似乎患有一种迄今尚未报道的临床病理实体。本文讨论了其与其他进行性肾小球损伤原因的鉴别，尤其是与局灶节段性肾小球硬化的鉴别。
