Cutrim Érico Murilo Monteiro, Neves Precil Diego Miranda de Meneses, Campos Marcos Adriano Garcia, Wanderley Davi Campos, Teixeira-Júnior Antonio Augusto Lima, Muniz Monique Pereira Rêgo, Ladchumananandasivam Francisco Rasiah, Gomes Orlando Vieira, Vasco Rafael Fernandes Vanderlei, Brito Dyego José de Araújo, Lages Joyce Santos, Salgado-Filho Natalino, Guedes Felipe Leite, de Almeida José Bruno, Magalhães Marcelo, Araújo Stanley de Almeida, Silva Gyl Eanes Barros
University Hospital, Federal University of Maranhão, São Luís, Brazil.
Clinical Hospital, University of São Paulo, São Paulo, Brazil.
Front Med (Lausanne). 2022 Mar 3;9:846173. doi: 10.3389/fmed.2022.846173. eCollection 2022.
Collapsing glomerulopathy (CG) is a clinicopathologic entity characterized by segmentar or global collapse of the glomerulus and hypertrophy and hyperplasia of podocytes. The Columbia classification of 2004 classified CG as a histological subtype of focal segmental glomerulosclerosis (FSGS). A growing number of studies have demonstrated a high prevalence of CG in many countries, especially among populations with a higher proportion of people with African descent. The present study is a narrative review of articles extracted from PubMed, Medline, and Scielo databases from September 1, 2020 to December 31, 2021. We have focused on populational studies (specially cross-sectional and cohort articles). CG is defined as a podocytopathy with a distinct pathogenesis characterized by strong podocyte proliferative activity. The most significant risk factors for CG include gene mutations and infections with human immunodeficiency virus and severe acute respiratory syndrome coronavirus 2. CG typically presents with more severe symptoms and greater renal damage. The prognosis is notably worse than that of other FSGS subtypes.
塌陷性肾小球病（CG）是一种临床病理实体，其特征为肾小球节段性或全球性塌陷以及足细胞肥大和增生。2004年的哥伦比亚分类将CG归类为局灶节段性肾小球硬化（FSGS）的一种组织学亚型。越来越多的研究表明，CG在许多国家的患病率很高，尤其是在非洲裔人口比例较高的人群中。本研究是对2020年9月1日至2021年12月31日从PubMed、Medline和Scielo数据库中提取的文章进行的叙述性综述。我们重点关注人群研究（特别是横断面研究和队列研究文章）。CG被定义为一种具有独特发病机制的足细胞病，其特征为强烈的足细胞增殖活性。CG最重要的危险因素包括基因突变、人类免疫缺陷病毒感染和严重急性呼吸综合征冠状病毒2感染。CG通常表现出更严重的症状和更大的肾损伤。其预后明显比其他FSGS亚型更差。
