自身免疫性肾小球肾炎小鼠肾小球中基底膜抗原的分布

Matsuo S, Brentjens J R, Andres G, Foidart J M, Martin G R, Martinez-Hernandez A

Am J Pathol. 1986 Jan;122(1):36-49.

Glomerulonephritis was induced in mice by the repeated injection of human glomeruli or purified glomerular basement membrane. The glomerular basement membranes of nephritic animals were observed to develop subepithelial extensions, "spikes." Although normally Type IV collagen is found throughout the full thickness of basement membranes, the "spikes" reacted with antibodies to laminin but not with antibodies to Type IV collagen. It is proposed that in murine autoimmune glomerulonephritis, the visceral epithelial cells produce an excess of laminin.

通过反复注射人肾小球或纯化的肾小球基底膜在小鼠中诱发肾小球肾炎。观察到肾炎动物的肾小球基底膜出现上皮下延伸，即“钉突”。虽然正常情况下IV型胶原存在于基底膜的全层，但“钉突”与层粘连蛋白抗体发生反应，而不与IV型胶原抗体发生反应。有人提出，在小鼠自身免疫性肾小球肾炎中，脏层上皮细胞会产生过量的层粘连蛋白。