(±)-Corysaxicolaine A：来自. 的一对抗肿瘤对映体生物碱二聚体

(±)-Corysaxicolaine A: a pair of antitumor enantiomeric alkaloid dimers from .

机构信息

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.

College of Biological and Food Engineering, Huanghuai University, Zhumadian 463000, China.

出版信息

Org Biomol Chem. 2022 Feb 16;20(7):1396-1400. doi: 10.1039/d1ob02334a.

DOI:10.1039/d1ob02334a

PMID:35106527

Abstract

(±)-Corysaxicolaine A (1), isolated from the aerial parts of for the first time, is a pair of novel dimeric alkaloids, each of which is directly coupled by the rare 6, 12' C-C σ-bond between benzophenanthridine and protoberberine. The enantiomeric separation was achieved using chiral chromatography. Their structures, including stereochemistry, were clarified by carrying out extensive spectroscopic techniques and an electronic circular dichroism (ECD) calculation. (-)-Corysaxicolaine A was observed to exhibit an apparent cytotoxic effect against T24 cells with an IC value of 9.45 μM.

摘要

（±）-Corysaxicolaine A（1），首次从的地上部分分离得到，是一对新型二聚生物碱，每个生物碱都是由苯并菲啶和原小檗碱之间罕见的 6,12' C-C σ 键直接偶联而成。通过手性色谱实现了对映体分离。通过广泛的光谱技术和电子圆二色性（ECD）计算确定了它们的结构，包括立体化学。（-）-Corysaxicolaine A 对 T24 细胞表现出明显的细胞毒性作用，IC 值为 9.45 μM。