Abdollahi Ali, Adelibahram Faeze, Ghassab-Abdollahi Nafiseh, Araj-Khodaei Mostafa, Parsian Zahra, Mirghafourvand Mojgan
Student Research Comittee, Aging Research Institute, Tabriz University of Medical sciences, Tabriz, Iran.
Student Research Comittee, Tabriz University of Medical sciences, Tabriz, Iran.
J Complement Integr Med. 2022 Jan 25;20(3):521-529. doi: 10.1515/jcim-2021-0425. eCollection 2023 Sep 1.
Diabetes is one of the most common endocrine disorders that increases the economic burden on the public health system. In this regard, understanding the effect of available herbs on diabetes can be useful. This systematic review was performed to determine the effect of on blood glycemic indexes and blood lipid profile (primary outcomes) and 2 h postprandial blood glucose (2HPPG), alanine transaminase (ALT) (U/L) and aspartate transaminase (AST) (U/L) and its side effects (secondary outcomes) in diabetic patients. A systematic search was conducted in the English (Cochrane Library, Medline (PubMed), Scopus, CINAHL, ProQuest and Persian databases since inception to March 2021, without publication time restriction. Two authors separately evaluated the quality of the articles using Cochrane Collaboration's tool for assessing the risk of bias in randomized trials and extracted the data. Heterogeneity of data was evaluated by squared ( ). Three studies included in the review and all of them included in meta-analysis. The results of meta-analysis showed that reduced fasting blood sugar (FBS) (mg/dL) (MD: -31.15; 95% CI: -37.56 to -24.73; p<0.00001). It also reduced HbA1c (%) (MD: -0.94; 95% CI: -1.25 to -0.63; p<0.00001) and total cholesterol (mg/dL) (MD: -43.64; 95% CI: -83.26 to -4.02; p=0.03) and reduction of low-density protein (LDL) (mg/dL) (MD: -19.23; 95% CI: -35.81 to -2.65; p=0.02) but it did not have a significant effect on triglyceride (mg/dL) (p=0.09), and high-density lipoprotein (HDL) (mg/dL) (p=0.18). Regarding the secondary outcomes, also had significant effect on 2HPPG, but it did not have a significant effect on ALT (U/L) and AST (U/L). No specific side effects for this plant were reported in these three studies. The results showed that has a positive effect on blood glycemic status and blood lipid profile in diabetes except for triglyceride and HDL. However, due to the small number of included articles, it is recommended that stronger clinical trials be conducted in this field.
糖尿病是最常见的内分泌疾病之一，增加了公共卫生系统的经济负担。在这方面，了解现有草药对糖尿病的影响可能会有所帮助。本系统评价旨在确定[草药名称]对糖尿病患者血糖指数和血脂谱（主要结局）以及餐后2小时血糖（2HPPG）、丙氨酸转氨酶（ALT）（U/L）和天冬氨酸转氨酶（AST）（U/L）及其副作用（次要结局）的影响。自数据库建立至2021年3月，在英文数据库（Cochrane图书馆、Medline（PubMed）、Scopus、CINAHL、ProQuest）和波斯文数据库中进行了系统检索，无发表时间限制。两位作者分别使用Cochrane协作网评估随机试验偏倚风险的工具评估文章质量并提取数据。数据异质性通过I²（I方）进行评估。该评价纳入了三项研究，所有研究均纳入荟萃分析。荟萃分析结果显示，[草药名称]降低了空腹血糖（FBS）（mg/dL）（MD：-31.15；95%CI：-37.56至-24.73；p<0.00001）。它还降低了糖化血红蛋白（HbA1c）（%）（MD：-0.94；95%CI：-1.25至-0.63；p<0.00001）和总胆固醇（mg/dL）（MD：-43.64；95%CI：-83.26至-4.02；p=0.03），并降低了低密度脂蛋白（LDL）（mg/dL）（MD：-19.23；95%CI：-35.81至-2.65；p=0.02），但对甘油三酯（mg/dL）（p=0.09）和高密度脂蛋白（HDL）（mg/dL）（p=0.18）没有显著影响。关于次要结局，[草药名称]对2HPPG也有显著影响，但对ALT（U/L）和AST（U/L）没有显著影响。这三项研究均未报告该植物有特定的副作用。结果表明，[草药名称]对糖尿病患者的血糖状态和血脂谱有积极影响，但对甘油三酯和高密度脂蛋白除外。然而，由于纳入的文章数量较少，建议在该领域开展更有力的临床试验。
