Jafarizadeh Ali, Raeisi Seyed Amin, Ghassab-Abdollahi Nafiseh, Yarani Reza, Araj-Khodaei Mostafa, Mirghafourvand Mojgan
Student Research Committee, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Health Education and Promotion, Faculty of Health Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
J Diabetes Metab Disord. 2022 Aug 5;21(2):1785-1795. doi: 10.1007/s40200-022-01045-9. eCollection 2022 Dec.
In this systematic review and meta-analysis, we investigated the effect and side effects of Citrullus colocynthis on glycemic factors and lipid profile in diabetic patients.
We systematically searched English and Persian databases from inception till August 2021 using Medical Subject Headings (MeSH). Two authors independently extracted data and assessed the quality of studies. The standardized mean differences were pooled using fixed-effect models, and statistical heterogeneity was assessed using the I squared (I²) index.
Of the 321 articles searched in the databases, 136 related articles were screened, 14 relevant full-text articles were assessed for eligibility; finally, four articles were included in the study, three articles were entered into the meta-analysis. The results of the meta-analysis indicated that does not have a significant effect on fasting blood sugar (FBS), hemoglobin A1c (HBA1c), low-density lipoprotein (LDL), total cholesterol, and triglyceride indices but increases high-density lipoprotein (HDL) (Mean Difference: 5.76; 95% CI: 1.69 to 9.84; P = 0.006; I = 0%).
The meta-analysis results showed that has no significant effect on glycemic and metabolic indices of diabetes - except HDL. Due to the relatively low quality and the small number of included trials, conducting further large scale well-designed randomized clinical trials to determine the effect of on glycemic and metabolic indices seems essential.
The online version contains supplementary material available at 10.1007/s40200-022-01045-9.
在本系统评价和荟萃分析中，我们研究了苦西瓜对糖尿病患者血糖因子和血脂谱的影响及副作用。
我们使用医学主题词（MeSH）从数据库建立至2021年8月系统检索了英文和波斯文数据库。两位作者独立提取数据并评估研究质量。使用固定效应模型汇总标准化均数差，并使用I²指数评估统计异质性。
在数据库中检索到的321篇文章中，筛选出136篇相关文章，评估了14篇相关全文文章的 eligibility；最终，4篇文章纳入研究，3篇文章纳入荟萃分析。荟萃分析结果表明，对空腹血糖（FBS）、糖化血红蛋白（HBA1c）、低密度脂蛋白（LDL）、总胆固醇和甘油三酯指数无显著影响，但可提高高密度脂蛋白（HDL）（均数差：5.76；95%可信区间：1.69至9.84；P = 0.006；I = 0%）。
荟萃分析结果表明，除HDL外，对糖尿病的血糖和代谢指标无显著影响。由于纳入试验的质量相对较低且数量较少，开展进一步大规模设计良好的随机临床试验以确定对血糖和代谢指标的影响似乎至关重要。
在线版本包含可在10.1007/s40200-022-01045-9获取的补充材料。
