Department of General medicine, Shaoxing People's Hospital, Shaoxing City, 312000, China.
Department of Thoracic surgery, Yidu Central Hospital of Weifang, Weifang City, 261000, China.
Future Oncol. 2022 Apr;18(13):1545-1555. doi: 10.2217/fon-2021-1530. Epub 2022 Feb 2.
The authors aimed to evaluate the prognostic value of Naples prognostic score (NPS) in advanced non-small-cell lung cancer patients with brain metastases. A total of 186 consecutive advanced non-small-cell lung cancer patients were retrospectively analyzed. Kaplan-Meier survival analysis and Cox proportional regression models were used to assess the significance of NPS in overall survival and disease-free survival. Multivariate Cox proportional regression analysis revealed that NPS was a significant independent predictive indicator for overall survival (hazard ratio: 1.897; 95% CI: 1.184-3.041; p = 0.008) and disease-free survival (hazard ratio: 2.169; 95% CI: 1.367-3.44; p = 0.001). NPS was a powerful prognostic indicator for outcome in advanced non-small-cell lung cancer patients with brain metastases.
作者旨在评估那不勒斯预后评分（NPS）在伴有脑转移的晚期非小细胞肺癌患者中的预后价值。对 186 例连续的晚期非小细胞肺癌患者进行了回顾性分析。采用 Kaplan-Meier 生存分析和 Cox 比例风险回归模型评估 NPS 对总生存期和无疾病生存期的意义。多因素 Cox 比例风险回归分析显示，NPS 是总生存期（风险比：1.897；95%可信区间：1.184-3.041；p=0.008）和无疾病生存期（风险比：2.169；95%可信区间：1.367-3.44；p=0.001）的显著独立预测指标。NPS 是伴有脑转移的晚期非小细胞肺癌患者预后的有力预测指标。
