Filimonow Katarzyna, Chołoniewska Anna, Michniak Katarzyna, Piliszek Anna
Instytut Genetyki i Biotechnologii Zwierząt Polskiej Akademii Nauk, Zakład Embriologii Doświadczalnej, Instytut Genetyki i Biotechnologii Zwierząt Polskiej Akademii Nauk, Jastrzębiec.
Laboratorium Badawcze - Bank Komórek, Centrum Badań Przedklinicznych i Technologii Warszawskiego Uniwersytetu Medycznego.
Postepy Biochem. 2022 Jan 12;67(4):370-382. doi: 10.18388/pb.2021_417. Print 2021 Dec 31.
The embryonic development of placental mammals takes place inside the mother’s womb, which requires the formation of appropriate supportive structures by both the mother’s organism and the developing embryo. The first stages of mammalian embryonic development, preceding implantation, are the period of differentiation of the first cell lineages – epiblast (which will give rise to the embryo proper), and extra-embryonic lineages: trophectoderm (responsible for implantation and formation of the placenta) and primitive endoderm (giving rise to the yolk sac). Their differentiation is necessary for further development, and is a common feature of the development of all placental mammals, but the timing and molecular mechanisms responsible for these processes differ between mammalian species.
胎盘哺乳动物的胚胎发育在母体子宫内进行，这需要母体机体和发育中的胚胎形成适当的支持结构。在着床前的哺乳动物胚胎发育的最初阶段，是第一批细胞谱系分化的时期——上胚层（将发育成胚胎本身）和胚外谱系：滋养外胚层（负责着床和胎盘形成）和原始内胚层（发育成卵黄囊）。它们的分化对于进一步发育是必要的，并且是所有胎盘哺乳动物发育的共同特征，但是负责这些过程的时间和分子机制在哺乳动物物种之间有所不同。
