Gomella L G, Gehrken G A, Hagihara P F, Flanigan R C
Dis Colon Rectum. 1986 Feb;29(2):99-101. doi: 10.1007/BF02555387.
The incidence of ischemic colitis in renal transplant recipients approaches 1 percent. The mortality in these patients with ischemic colitis is nearly 70 percent. Immunosuppressive agents have been implicated in the development of ischemic colitis. To study the effect of immunosuppressive agents on ischemic colitis, a 4-cm segment of the colon was devascularized in 27 male Fischer rats. The animals were divided into one control and two treatment groups. One treatment group received methylprednisolone and the other, azathioprine, in doses similar to those of renal transplant recipients. Both experimental groups, either separately or combined, showed significantly greater areas of colonic ischemic changes than did the control group. This study demonstrates that systemic administration of immunosuppressive agents may augment the development of ischemic colitis.
肾移植受者中缺血性结肠炎的发病率接近1%。这些患有缺血性结肠炎的患者死亡率近70%。免疫抑制剂被认为与缺血性结肠炎的发生有关。为研究免疫抑制剂对缺血性结肠炎的影响，在27只雄性费希尔大鼠中使一段4厘米长的结肠缺血。将这些动物分为一个对照组和两个治疗组。一个治疗组接受甲泼尼龙，另一个接受硫唑嘌呤，剂量与肾移植受者相似。两个实验组单独或联合使用时，结肠缺血改变的面积均显著大于对照组。这项研究表明，全身给予免疫抑制剂可能会加剧缺血性结肠炎的发展。
