Gomella L G, Flanigan R C, Hagihara P F, Lucas B A, McRoberts J W
Dis Colon Rectum. 1986 Nov;29(11):724-7. doi: 10.1007/BF02555319.
Up to 1 percent of renal transplant recipients have been reported to develop ischemic colitis. Immunosuppressive agents and uremia have been implicated in the development of this complication, but their exact relationship remains unclear. A rat model was developed to determine the effects of uremia alone and in combination with immunosuppression on the development of ischemic colitis. Seventy-six animals were included in the study. Uremia and ischemic colitis were induced surgically. The immunosuppressive agents azathioprine and methylprednisolone were administered for 72 hours after a colonic segment was devascularized in chronically uremic rats. One-way analysis of variance (ANOVA) showed that uremia potentiates colonic ischemia significantly (4.09 cm2 vs 1.25 cm2, P less than 0.03). The addition of parenteral steroids (methylprednisolone) or azathioprine alone and in combination did not potentiate or reduce this ischemic process in uremic animals. Each of these factors alone is commonly present in the renal transplant population and can contribute to the development of potentially fatal ischemic colitis.
据报道，高达1%的肾移植受者会发生缺血性结肠炎。免疫抑制剂和尿毒症被认为与这种并发症的发生有关，但其确切关系仍不清楚。建立了一个大鼠模型，以确定单独的尿毒症以及与免疫抑制联合使用对缺血性结肠炎发生的影响。该研究纳入了76只动物。通过手术诱导尿毒症和缺血性结肠炎。在慢性尿毒症大鼠的一段结肠血管化后，给予免疫抑制剂硫唑嘌呤和甲基强的松龙72小时。单因素方差分析（ANOVA）显示，尿毒症显著增强结肠缺血（4.09平方厘米对1.25平方厘米，P小于0.03）。单独或联合使用胃肠外类固醇（甲基强的松龙）或硫唑嘌呤，并不会增强或减轻尿毒症动物的这种缺血过程。这些因素中的每一个在肾移植人群中都很常见，并且都可能导致潜在致命的缺血性结肠炎的发生。
