Demma I, Houssin D, Capron M, Minato M, Morin J, Gigou M, Szekely A M, Bismuth H
Eur Surg Res. 1986;18(1):12-8. doi: 10.1159/000128500.
In this study, the beneficial effect of intrasplenic transplantation of hepatocytes or splenocytes was shown in animals with 75% hepatectomy and portacaval shunt but not in animals with total dehepatization by hepatic vascular exclusion. No enhancement of the phagocytic activity was observed in the animals with 75% hepatectomy and portacaval shunt after injection of hepatocytes or splenocytes. This study confirms the efficacy of hepatocytes for the treatment of experimental liver failure but shows that nonhepatic cells may be equally as effective. Metabolic activity of the transplanted cells and stimulation of the phagocytic activity of the reticuloendothelial system probably do not explain the therapeutic effect of the transplanted cells.
在本研究中，肝细胞或脾细胞脾内移植对75%肝切除及门腔分流动物显示出有益效果，但对肝血管阻断致全肝去血供的动物则未显示出有益效果。在75%肝切除及门腔分流的动物中，注射肝细胞或脾细胞后未观察到吞噬活性增强。本研究证实了肝细胞治疗实验性肝衰竭的有效性，但表明非肝细胞可能同样有效。移植细胞的代谢活性及网状内皮系统吞噬活性的刺激可能无法解释移植细胞的治疗效果。
