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严重凝血病患者的短肠综合征。

Severe Coagulopathy in a Patient With Short Bowel Syndrome.

机构信息

Department of Emergency Medicine, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.

Intensive Care Unit, Department of Internal Medicine, Okinawa Chubu Hospital, Uruma, Okinawa, Japan; Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Kanagawa, Japan.

出版信息

J Emerg Med. 2022 May;62(5):e101-e104. doi: 10.1016/j.jemermed.2021.12.006. Epub 2022 Jan 31.

DOI:10.1016/j.jemermed.2021.12.006
PMID:35109974
Abstract

BACKGROUND

Short bowel syndrome (SBS) refers to a malabsorptive state caused by extensive resection of the intestinal tract that leads to chronic diarrhea, electrolyte disturbances, and malnutrition. Although relatively uncommon, patients with SBS can present to the emergency department with more serious complications that are potentially life-threatening. Among these complications, coagulopathy secondary to SBS is an underrecognized condition.

CASE REPORT

We present a case of severe coagulopathy secondary to vitamin K deficiency in SBS. The patient presented with unexplained coagulopathy and spontaneous bleeding in multiple organs. With a review of surgical history and detailed clinical evaluation, SBS complicated with vitamin K deficiency was diagnosed, and the patient was treated successfully. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: When a patient with a history of repeated intestinal surgery presents with diarrhea, malnutrition, or electrolyte abnormalities, emergency physicians should suspect SBS. Among complications of SBS, vitamin K deficiency is a rare but serious cause of unexplained coagulopathy presenting to the emergency department. Understanding the pathophysiology of SBS facilitates early identification of complications and improves patient outcomes.

摘要

背景

短肠综合征(SBS)是指由于广泛的肠道切除导致的吸收不良状态,导致慢性腹泻、电解质紊乱和营养不良。尽管相对少见,但 SBS 患者可能会因潜在危及生命的更严重并发症而到急诊科就诊。在这些并发症中,SBS 引起的凝血功能障碍是一种认识不足的情况。

病例报告

我们报告了一例 SBS 继发于维生素 K 缺乏的严重凝血功能障碍。该患者表现为不明原因的凝血功能障碍和多个器官自发性出血。通过回顾手术史和详细的临床评估,诊断为 SBS 合并维生素 K 缺乏,并成功治疗了该患者。

为什么急诊医生应该了解这个情况?:当有反复肠道手术史的患者出现腹泻、营养不良或电解质异常时,急诊医生应怀疑 SBS。在 SBS 的并发症中,维生素 K 缺乏是一种罕见但严重的原因不明的凝血功能障碍,会导致患者到急诊科就诊。了解 SBS 的病理生理学有助于早期识别并发症并改善患者的结局。

相似文献

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Severe Coagulopathy in a Patient With Short Bowel Syndrome.严重凝血病患者的短肠综合征。
J Emerg Med. 2022 May;62(5):e101-e104. doi: 10.1016/j.jemermed.2021.12.006. Epub 2022 Jan 31.
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Spectrum of short bowel syndrome in adults: intestinal insufficiency to intestinal failure.成人短肠综合征的范围:从肠道功能不全到肠道衰竭。
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Fat malabsorption in short bowel syndrome: A review of pathophysiology and management.短肠综合征中的脂肪吸收不良:病理生理学和治疗的综述。
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Coagulopathy secondary to vitamin K deficiency in hyperemesis gravidarum.妊娠剧吐继发维生素K缺乏所致的凝血功能障碍。
Obstet Gynecol. 1998 Oct;92(4 Pt 2):673-5. doi: 10.1016/s0029-7844(98)00150-1.
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Vitamin K status in patients with short bowel syndrome.短肠综合征患者的维生素 K 状态。
Clin Nutr. 2012 Dec;31(6):1015-7. doi: 10.1016/j.clnu.2012.04.014. Epub 2012 May 26.
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Short bowel syndrome: Complications and management.短肠综合征:并发症与管理
Nutr Clin Pract. 2023 May;38 Suppl 1:S46-S58. doi: 10.1002/ncp.10978.
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Short Bowel Syndrome in an Infant.婴儿短肠综合征。
Neoreviews. 2020 Jun;21(6):e370-e382. doi: 10.1542/neo.21-6-e370.
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[Short bowel syndrome in children: a diagnosis and management update].[儿童短肠综合征:诊断与管理的最新进展]
Rev Gastroenterol Mex. 2012 Jul-Sep;77(3):130-40. doi: 10.1016/j.rgmx.2012.06.001. Epub 2012 Aug 24.
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