肥胖与 COVID-19 感染和严重程度的关系：现有证据和机制。
Obesity and Risk of COVID-19 Infection and Severity: Available Evidence and Mechanisms.
机构信息
Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
出版信息
Adv Exp Med Biol. 2021;1321:97-107. doi: 10.1007/978-3-030-59261-5_8.
The coronavirus disease 2019 (COVID-19) pandemic has resulted in worldwide research efforts to recognize people at greatest risk of developing critical illness and dying. Growing numbers of reports have connected obesity to more severe COVID-19 illness and death. Although the exact mechanism by which obesity may lead to severe COVID-19 outcomes has not yet been determined, the mechanisms appear to be multifactorial. These include mechanical changes of the airways and lung parenchyma, systemic and airway inflammation, and general metabolic dysfunction that adversely affect pulmonary function and/or response to treatment. As COVID-19 continues to spread worldwide, clinicians should carefully monitor and manage obese patients for prompt and targeted treatment.
2019 年冠状病毒病（COVID-19）大流行促使全世界开展研究，以识别有发展为重症和死亡风险的高危人群。越来越多的报告将肥胖与更严重的 COVID-19 疾病和死亡联系起来。虽然肥胖导致严重 COVID-19 结局的确切机制尚未确定，但这些机制似乎是多因素的。这些因素包括气道和肺实质的机械变化、全身和气道炎症以及一般代谢功能障碍，这些因素对肺功能和/或治疗反应产生不利影响。随着 COVID-19 在全球范围内继续传播，临床医生应仔细监测和管理肥胖患者，以便及时进行有针对性的治疗。
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