Gurajala Indira, Jayaram Kavitha, Mudavot Priyanka, Durga Padmaja
Department of Anaesthesiology and Critical Care, Nizam's Institute of Medical Sciences, Hyderabad, India.
Turk J Anaesthesiol Reanim. 2021 Jun;49(3):218-223. doi: 10.5152/TJAR.2020.29.
Amino acids attenuate hypothermia during the perioperative period by increasing thermogenesis and stimulating energy consumption. Percutaneous nephrolithotomy (PCNL) induces profound hypothermia owing to the use of large volumes of irrigating fluids. The role of amino acids in this group of surgeries for hypothermia and shivering prevention has been evaluated in this study because there is no available literature of concern.
This prospective randomised controlled trial was conducted in patients undergoing PCNL. Group A received amino acids at 60 mL h-1 an hour before surgery until the end of surgery. Group C received normal saline infusion. Perioperative nasopharyngeal temperature, haemodynamics, and postoperative shivering were recorded.
Although there was no significant difference in temperature in the intraoperative period, postoperative decrease in the temperature was less in the amino acid group. In the postoperative period, 2 patients in the amino acid group and 11 patients in the control group experienced shivering.
Intravenous administration of amino acids attenuated postoperative hypothermia and reduced shivering in patients undergoing PCNL without any adverse effects.
氨基酸通过增加产热和刺激能量消耗来减轻围手术期的体温过低。经皮肾镜取石术（PCNL）由于使用大量冲洗液会导致深度体温过低。由于缺乏相关文献，本研究评估了氨基酸在这类手术中预防体温过低和寒战的作用。
本前瞻性随机对照试验在接受PCNL的患者中进行。A组在手术前1小时以60 mL h-1的速度输注氨基酸直至手术结束。C组输注生理盐水。记录围手术期鼻咽温度、血流动力学和术后寒战情况。
虽然术中体温无显著差异，但氨基酸组术后体温下降较少。术后，氨基酸组有2例患者发生寒战，对照组有11例患者发生寒战。
静脉输注氨基酸可减轻接受PCNL患者的术后体温过低，并减少寒战，且无任何不良反应。
