胎儿编程：肺部健康与疾病
Fetal Programming: Lung Health and Disease.
作者信息
Yilmaz Ozge, Yuksel Hasan, Buist A Sonia
机构信息
Department of Pediatric Allergy and Pulmonology, Celal Bayar University, Manisa, Izmir, Turkey.
Oregon Health - Science University, Portland, Oregon, USA.
出版信息
Turk Thorac J. 2021 Sep;22(5):413-417. doi: 10.5152/TurkThoracJ.2021.0196.
Fetal programming is a mechanism whereby stimuli acting on the developing fetus influence the development of the fetus in a way that may set the stage for adult health and disease. These stimuli may be environmental, such as maternal smoking; metabolic, such as the maternal diet and nutrition; or endocrine, such as diabetes or stress, and may extend over several generations. The endocrine system influences fetal programming with effects of insulin, thyroid hormones, and glucocorticoid hormones. Epigenetic information may be modified by DNA methylation, histone modifications, and micro RNAs due to environmental exposures. In this review, we describe the normal development of the lungs and the major factors that may influence lung growth and development with the potential for sequelae into adult life.
胎儿编程是一种机制，通过该机制作用于发育中胎儿的刺激因素，以可能为成人健康和疾病奠定基础的方式影响胎儿的发育。这些刺激因素可能是环境因素，如母亲吸烟；代谢因素，如母亲的饮食和营养；或内分泌因素，如糖尿病或压力，并且可能会延续几代人。内分泌系统通过胰岛素、甲状腺激素和糖皮质激素的作用影响胎儿编程。由于环境暴露，表观遗传信息可能会通过DNA甲基化、组蛋白修饰和微小RNA发生改变。在本综述中，我们描述了肺的正常发育以及可能影响肺生长和发育并有可能导致成年后患后遗症的主要因素。
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