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接种 ChAdOx1 nCoV-19 后可逆转性脊神经根脊髓炎。

Reversible radiculomyelitis after ChAdOx1 nCoV-19 vaccination.

机构信息

Department of Biomedicine, Neuroscience and Advanced Diagnostics, ALS Clinical Research Center, University of Palermo, Palermo, Italy.

IRCCS Centro Neurolesi Bonino Pulejo, Palermo, Italy.

出版信息

BMJ Case Rep. 2022 Feb 2;15(2):e247472. doi: 10.1136/bcr-2021-247472.

Abstract

Adverse events occurring after SARS-CoV-2 vaccination have been reported and are the subject of ongoing research. We present the case of a young woman with fully reversible radiculomyelitis, which happened after the first dose of the ChAdOx1 nCOVID-19 vaccine. A previously healthy woman in her 20s presented with a subacute onset of legs' weakness and sensory disturbances, urinary dysfunction and cramping pain after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. A diagnostic workup led to the diagnosis of inflammatory radiculomyelitis. Her clinical status improved, with complete recovery after a few months. The case described a reversible radiculomyelitis associated with the ChAdOx1 nCOVID-19 vaccine. The clinical picture and evolution supported the diagnosis. No other identifiable causes of myelopathy were found. Our patient showed clinically moderate symptoms and signs, showing good recovery. The post-vaccine inflammatory radiculomyelitis is a rare side effect of the anti-COVID-19 vaccination, and it should not discourage the SARS-CoV-2 vaccination programme.

摘要

接种 SARS-CoV-2 疫苗后出现的不良反应已被报道,并正在进行研究。我们报告了一例年轻女性在接种第一剂 ChAdOx1 nCOVID-19 疫苗后发生完全可逆性神经根脊髓炎的病例。一位 20 多岁的既往健康女性在接种第一剂 ChAdOx1 nCoV-19 疫苗后出现亚急性下肢无力和感觉障碍、尿功能障碍和痉挛性疼痛。诊断性检查导致炎症性神经根脊髓炎的诊断。她的临床状况有所改善,几个月后完全康复。所描述的病例为与 ChAdOx1 nCOVID-19 疫苗相关的可逆性神经根脊髓炎。临床表现和演变支持该诊断。未发现其他可识别的脊髓病病因。我们的患者表现出临床中度症状和体征,恢复良好。疫苗接种后炎症性神经根脊髓炎是抗 COVID-19 疫苗接种的罕见副作用,不应阻止 SARS-CoV-2 疫苗接种计划。

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