Beaulieu-Saucier Université de Montréal Pharmacogenomics Centre, Montreal, QC, Canada.
Montreal Heart Institute, Montreal, QC, Canada.
Sci Rep. 2022 Feb 2;12(1):1780. doi: 10.1038/s41598-022-05713-x.
Gender captures social components beyond biological sex and can add valuable insight to health studies in populations. However, assessment of gender typically relies on questionnaires which may not be available. The aim of this study is to construct a gender metric using available variables in the UK Biobank and to apply it to the study of angina diagnosis. Proxy variables for femininity characteristics were identified in the UK Biobank and regressed on sex to construct a composite femininity score (FS) validated using tenfold cross-validation. The FS was assessed as a predictor of angina diagnosis before incident myocardial infarction (MI) events. The FS was derived for 315,937 UK Biobank participants. In 3059 individuals with no history of MI at study entry who had an incident MI event, the FS was a significant predictor of angina diagnosis prior to MI (OR 1.24, 95% CI 1.10-1.39, P < 0.001) with a significant sex-by-FS interaction effect (P = 0.003). The FS was positively associated with angina diagnosis prior to MI in men (OR 1.37, 95% CI 1.19-1.57, P < 0.001), but not in women. We have provided a new tool to conduct gender-sensitive analyses in observational studies, and applied it to study of angina diagnosis prior to MI.
性别不仅包含生物学性别方面的社会因素，还能为人群健康研究提供有价值的见解。然而，对性别的评估通常依赖于调查问卷，而这些问卷可能并不存在。本研究旨在利用英国生物库中可用的变量构建一个性别衡量指标，并将其应用于心绞痛诊断的研究。在英国生物库中确定了女性化特征的替代变量，并对其进行回归分析，以构建一个复合女性化评分（FS），并使用十折交叉验证进行验证。该 FS 用于评估心肌梗死（MI）事件前心绞痛的诊断。FS 是为 315937 名英国生物库参与者推导的。在 3059 名研究开始时没有 MI 病史且发生 MI 事件的个体中，FS 是 MI 前心绞痛诊断的显著预测因子（OR 1.24，95%CI 1.10-1.39，P<0.001），且性别与 FS 的交互作用具有统计学意义（P=0.003）。FS 与 MI 前心绞痛诊断呈正相关（OR 1.37，95%CI 1.19-1.57，P<0.001），但在女性中没有相关性。我们提供了一个新工具，用于在观察性研究中进行性别敏感分析，并将其应用于 MI 前心绞痛的研究。
