Lanks K W
J Cell Physiol. 1986 Feb;126(2):319-21. doi: 10.1002/jcp.1041260224.
L929 cells synthesize relatively little lactate when using glucose as their primary energy source, and neither glucose oxidation nor lactate production is highly sensitive to stimulation by insulin. Addition of glutamine to the system containing glucose and insulin markedly stimulates lactate production from glucose without inhibiting glucose oxidation. A mechanism in which reducing equivalents derived from glutamine oxidation are used to drive lactate production is discussed.
当以葡萄糖作为主要能量来源时，L929细胞合成的乳酸相对较少，并且葡萄糖氧化和乳酸生成对胰岛素刺激均不高度敏感。在含有葡萄糖和胰岛素的体系中添加谷氨酰胺，可显著刺激由葡萄糖生成乳酸，而不抑制葡萄糖氧化。本文讨论了一种机制，即谷氨酰胺氧化产生的还原当量被用于驱动乳酸生成。
