• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胃静脉曲张出血的罕见病因

A Rare Cause of Gastric Variceal Bleeding.

作者信息

Ramos Yesenia, Gui Dorina, Chak Eric

机构信息

Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, California, USA.

Department of Pathology, University of California Davis School of Medicine, Sacramento, California, USA.

出版信息

Case Rep Gastroenterol. 2021 Dec 30;15(3):1008-1012. doi: 10.1159/000521126. eCollection 2021 Sep-Dec.

DOI:10.1159/000521126
PMID:35110989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8787550/
Abstract

A 68-year-old woman with stage III colon cancer status after right hemicolectomy and adjuvant FOLFOX (5-fluorouracil/leucovorin/oxaliplatin) chemotherapy was hospitalized for melena and found to have new-onset esophageal and gastric varices on esophagogastroduodenoscopy. Her workup did not reveal an underlying liver disease, but her liver biopsy showed noncirrhotic portal hypertension from obliterative portal venopathy (OPV). The development of OPV is likely from her use of oxaliplatin-based chemotherapy.

摘要

一名68岁女性，右半结肠切除术后处于III期结肠癌状态，并接受了辅助性FOLFOX（5-氟尿嘧啶/亚叶酸钙/奥沙利铂）化疗，因黑便入院，经食管胃十二指肠镜检查发现新发食管和胃静脉曲张。她的检查未发现潜在的肝脏疾病，但肝脏活检显示为闭塞性门静脉病（OPV）导致的非肝硬化性门静脉高压。OPV的发生可能与她使用含奥沙利铂的化疗有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abe/8787550/f9492878a458/crg-0015-1008-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abe/8787550/4b179e84b233/crg-0015-1008-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abe/8787550/33d9b6fbfebb/crg-0015-1008-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abe/8787550/f9492878a458/crg-0015-1008-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abe/8787550/4b179e84b233/crg-0015-1008-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abe/8787550/33d9b6fbfebb/crg-0015-1008-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abe/8787550/f9492878a458/crg-0015-1008-g03.jpg

相似文献

1
A Rare Cause of Gastric Variceal Bleeding.胃静脉曲张出血的罕见病因
Case Rep Gastroenterol. 2021 Dec 30;15(3):1008-1012. doi: 10.1159/000521126. eCollection 2021 Sep-Dec.
2
Obliterative Portal Venopathy Caused by Oral Contraceptive Pills: A Case Report.口服避孕药导致的闭塞性门静脉病：一例报告
J Med Cases. 2021 Nov;12(11):446-450. doi: 10.14740/jmc3779. Epub 2021 Nov 5.
3
A Rare Case of Gastric Variceal Hemorrhage Secondary to Infiltrative B-Cell Lymphoma.1例浸润性B细胞淋巴瘤继发胃静脉曲张出血的罕见病例。
Case Rep Gastroenterol. 2016 Oct 6;10(3):518-524. doi: 10.1159/000445184. eCollection 2016 Sep-Dec.
4
Colorectal cancer surgery in portal hypertensive patients: does adjuvant oxaliplatin affect prognosis?门静脉高压症患者的结直肠癌手术：辅助奥沙利铂是否影响预后？
Dis Colon Rectum. 2013 May;56(5):577-85. doi: 10.1097/DCR.0b013e318286f8fc.
5
Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work.肝门静脉硬化（闭塞性门静脉病）和重症肌无力患者的结节性再生性增生：病例报告及文献复习。
Hepatol Res. 2013 Sep;43(9):999-1003. doi: 10.1111/hepr.12045. Epub 2013 May 15.
6
[A case of portal hypertension after 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) chemotherapy].[一例5-氟尿嘧啶、亚叶酸钙和奥沙利铂（mFOLFOX6）化疗后门静脉高压病例]
Nihon Shokakibyo Gakkai Zasshi. 2013 Dec;110(12):2119-26.
7
Endoscopic treatment of gastroesophageal variceal bleeding after oxaliplatin-based chemotherapy in patients with colorectal cancer.结直肠肿瘤患者奥沙利铂化疗后胃食管静脉曲张出血的内镜治疗。
Endoscopy. 2020 Sep;52(9):727-735. doi: 10.1055/a-1157-8611. Epub 2020 May 7.
8
Color Doppler evaluation of left gastric vein hemodynamics in cirrhosis with portal hypertension and its correlation with esophageal varices and variceal bleed.彩色多普勒评估肝硬化门静脉高压患者胃左静脉血流动力学及其与食管静脉曲张和曲张静脉出血的相关性
Indian J Radiol Imaging. 2010 Nov;20(4):289-93. doi: 10.4103/0971-3026.73541.
9
Noncirrhotic portal hypertension in the adult: case report and review of the literature.成人非肝硬化性门静脉高压症：病例报告及文献复习
J Assoc Acad Minor Phys. 1998;9(3):53-5.
10
Porto-Sinusoidal Vascular Disease as the Cause of Portal Hypertension in Felty's Syndrome: A Case Report and Literature Review.特发性门脉高压伴脾大症（Felty's syndrome）并发窦前性门静脉高压的病因：病例报告及文献复习。
Biomed Res Int. 2020 Jul 1;2020:2618260. doi: 10.1155/2020/2618260. eCollection 2020.

本文引用的文献

1
Adjuvant Chemotherapy for Stage III Colon Cancer.III期结肠癌的辅助化疗
Cancers (Basel). 2020 Sep 19;12(9):2679. doi: 10.3390/cancers12092679.
2
Surgical intervention for portal hypertension caused by oxaliplatin-based chemotherapy: a case report and a review of literature regarding radiological and/or surgical interventions for oxaliplatin-associated portal hypertension.基于奥沙利铂化疗所致门静脉高压症的外科干预：一例病例报告及关于奥沙利铂相关性门静脉高压症放射学和/或外科干预的文献综述
Clin J Gastroenterol. 2020 Oct;13(5):799-805. doi: 10.1007/s12328-020-01157-w. Epub 2020 Jun 26.
3
Incidence of portal hypertension in patients exposed to oxaliplatin.
接受奥沙利铂治疗的患者门静脉高压症的发病率。
Dig Liver Dis. 2019 Sep;51(9):1348-1350. doi: 10.1016/j.dld.2019.06.020. Epub 2019 Jul 15.
4
Noncirrhotic portal hypertension: Medical and endoscopic management.非肝硬化性门静脉高压症：医学与内镜治疗
Clin Liver Dis (Hoboken). 2015 Dec 9;6(5):107-111. doi: 10.1002/cld.511. eCollection 2015 Nov.
5
Idiopathic noncirrhotic portal hypertension: What is it?特发性非肝硬化性门静脉高压症：它是什么？
Clin Liver Dis (Hoboken). 2015 May 27;5(5):120-122. doi: 10.1002/cld.472. eCollection 2015 May.
6
The pathological differential diagnosis of portal hypertension.门静脉高压症的病理鉴别诊断
Clin Liver Dis (Hoboken). 2017 Sep 29;10(3):57-62. doi: 10.1002/cld.655. eCollection 2017 Sep.
7
Oxaliplatin-induced hepatoportal sclerosis, portal hypertension, and variceal bleeding successfully treated with transjugular intrahepatic portosystemic shunt.奥沙利铂诱导的肝门脉硬化、门静脉高压和静脉曲张出血经颈静脉肝内门体分流术成功治疗。
Clin Colorectal Cancer. 2012 Sep;11(3):224-7. doi: 10.1016/j.clcc.2012.02.002. Epub 2012 Apr 25.
8
Efficacy of non-selective β-blockers as adjunct to endoscopic prophylactic treatment for gastric variceal bleeding: a randomized controlled trial.非选择性β受体阻滞剂辅助内镜预防性治疗胃静脉曲张出血的疗效：一项随机对照试验。
J Hepatol. 2012 May;56(5):1025-1032. doi: 10.1016/j.jhep.2011.12.021. Epub 2012 Jan 17.
9
Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury.奥沙利铂介导的脾脏增大可作为肝窦损伤发展的生物标志物。
J Clin Oncol. 2010 May 20;28(15):2549-55. doi: 10.1200/JCO.2009.27.5701. Epub 2010 Apr 20.
10
Portal hypertension associated with oxaliplatin administration: clinical manifestations of hepatic sinusoidal injury.与奥沙利铂给药相关的门静脉高压：肝窦损伤的临床表现
Clin Colorectal Cancer. 2009 Oct;8(4):225-30. doi: 10.3816/CCC.2009.n.038.