Ashraf Muhammad Farhan, Trifonova Radiana, Batool Asra
Department of Internal Medicine, Albany Medical Center, NY, USA.
Department of Pathology, Albany Medical Center, NY, USA.
J Med Cases. 2021 Nov;12(11):446-450. doi: 10.14740/jmc3779. Epub 2021 Nov 5.
Oral contraceptive pills (OCPs) have a known prothrombotic effect. Obliterative portal venopathy (OPV) can be seen in patients with underlying hypercoagulability. We present a case of a 19-year-old female patient taking OCPs who presented with obstructive jaundice. Her main concern was pruritis. An extensive workup was done to reach a diagnosis but it came back negative. A liver biopsy showed OPV. This was thought secondary to her OCP use. Her OCPs were discontinued which resulted in a complete resolution of her symptoms and laboratory abnormalities. Cases with a direct relationship between OPV and OCP use are extremely rare. More studies are required to establish a correlation between OPV and OCPs. OPV should be considered in the differential diagnosis among patients with obstructive jaundice without an obvious cause, especially in patients taking OCPs. Treatment is stopping the OCPs with close follow-up to confirm disease resolution.
口服避孕药（OCPs）具有已知的促血栓形成作用。潜在高凝状态的患者可出现闭塞性门静脉病（OPV）。我们报告一例19岁服用OCPs的女性患者，该患者出现梗阻性黄疸。她主要的问题是瘙痒。进行了全面检查以明确诊断，但结果均为阴性。肝脏活检显示为OPV。考虑这是她服用OCPs所致。停用她的OCPs后，其症状和实验室异常完全缓解。OPV与OCPs使用之间存在直接关联的病例极为罕见。需要更多研究来确立OPV与OCPs之间的相关性。对于无明显病因的梗阻性黄疸患者，尤其是服用OCPs的患者，鉴别诊断时应考虑OPV。治疗方法是停用OCPs并密切随访以确认疾病缓解。
