Taylor C J, Hart A, Batt R M, McDougall C, McLean L
J Pediatr Gastroenterol Nutr. 1986 Jan;5(1):70-3. doi: 10.1097/00005176-198601000-00013.
A case of prolonged diarrhoea following Escherichia coli 0111 gastroenteritis is reported. Electron microscopy of the jejunal biopsy revealed effacement of the brush border and attachment of bacteria by pedestal formation. Specific activities of brush border enzymes showed marked depression of disaccharidases, zinc-resistant alpha-glucosidase, and alkaline phosphatase. In contrast, marker enzymes for basolateral membranes and endoplasmic reticulum were unaffected. The biochemical changes support the pathogenic mechanism suggested by ultrastructural studies previously reported.
报告了一例大肠杆菌O111肠胃炎后出现的长期腹泻病例。空肠活检的电子显微镜检查显示刷状缘消失，细菌通过基座形成附着。刷状缘酶的比活性显示双糖酶、耐锌α-葡萄糖苷酶和碱性磷酸酶明显降低。相比之下，基底外侧膜和内质网的标记酶未受影响。这些生化变化支持了先前报道的超微结构研究所提出的致病机制。
