Peng T K, Nisengard R J, Levine M J
J Periodontol. 1986 Jan;57(1):20-4. doi: 10.1902/jop.1986.57.1.20.
The gingival basement membrane antigens, Type IV collagen, bullous pemphigoid antigen and epidermolysis bullosa acquisita antigen were studied by indirect immunofluorescence in 11 gingival specimens from patients with periodontitis and 2 normal gingival specimens. In the normal control gingival specimens, the antigens were all present and stained with a continuous linear pattern. In periodontitis, alterations occurred in the gingival basement membrane antigens in the apical portion of the pockets. These included thinning, interruptions, partial or complete absence involving one or more rete pegs and fragmentation. These alterations may result form the disease process or play a role in the pathogenesis.
通过间接免疫荧光法，对11例牙周炎患者的牙龈标本和2例正常牙龈标本进行了研究，观察牙龈基底膜抗原、IV型胶原、大疱性类天疱疮抗原和获得性大疱性表皮松解症抗原。在正常对照牙龈标本中，所有抗原均存在，且呈连续线性染色模式。在牙周炎中，牙周袋顶部的牙龈基底膜抗原发生改变，包括变薄、中断、部分或完全缺失，累及一个或多个上皮嵴，以及断裂。这些改变可能是疾病过程的结果，或在发病机制中起作用。
