Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China.
J Clin Periodontol. 2022 Apr;49(4):335-344. doi: 10.1111/jcpe.13598. Epub 2022 Feb 23.
This Mendelian randomization (MR) study was performed to explore the causal relationship among circulating vitamin C and D levels, dental caries, and periodontitis.
MR analyses were conducted with the inverse variance weighted (IVW) method, weighted median, MR-Egger approaches, and MR-robust adjusted profile score method to assess the causal relationships between circulating vitamin C and D concentrations and dental caries, the number of remaining natural permanent teeth in the mouth (N teeth), and periodontitis.
We found potential causal association of circulating vitamin D concentrations with N teeth (β = 0.085; 95% confidence interval: 0.019 to 0.150; p = .012) based on the IVW method. No significant causal relationship between circulating vitamin D levels and dental caries and periodontitis was observed. Similarly, no evidence supported a causal relationship between circulating vitamin C concentrations and the risk of dental caries, N teeth, and periodontitis.
There is no obvious evidence suggesting a causal relationship among circulating vitamin D, dental caries, and periodontitis, drawing into question the mechanism for any association with N teeth. Additionally, there is insufficient power to detect small effects in vitamin C levels and caries and periodontitis.
本孟德尔随机化（MR）研究旨在探讨循环维生素 C 和 D 水平、龋齿和牙周炎之间的因果关系。
采用逆方差加权（IVW）法、加权中位数、MR-Egger 法和 MR-稳健调整轮廓评分法进行 MR 分析，以评估循环维生素 C 和 D 浓度与龋齿、口腔中剩余天然恒牙数（N 牙）和牙周炎之间的因果关系。
我们发现，根据 IVW 方法，循环维生素 D 浓度与 N 牙之间存在潜在的因果关联（β=0.085；95%置信区间：0.019 至 0.150；p=0.012）。未观察到循环维生素 D 水平与龋齿和牙周炎之间存在因果关系。同样，没有证据支持循环维生素 C 浓度与龋齿、N 牙和牙周炎风险之间存在因果关系。
没有明显证据表明循环维生素 D、龋齿和牙周炎之间存在因果关系，这对 N 牙与任何关联的机制提出了质疑。此外，维生素 C 水平和龋齿以及牙周炎的因果关系的检测能力不足。
