Shen Cheng, Chen Zhan, Zhang Wei, Chen Xinfeng, Zheng Bing, Shi Chunmei
Department of Urology, Affiliated Hospital 2 of Nantong University, Nantong, 226001, China.
Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China.
BMC Med Genomics. 2024 Jan 25;17(1):35. doi: 10.1186/s12920-024-01812-y.
Dysbacteriosis of intestinal tract may cause systemic inflammation, making distant anatomical locations more susceptible to illness. Recent research has demonstrated that the microbiome can affect both prostatitis and the inflammation of the prostate that is linked to prostate cancer. It is still unclear, though, whether this relationship indicates causation. We conducted a Mendelian randomization investigation on two samples to fully uncover gut microbiota's potential genetic causal role in prostatitis.
Prostatitis (1859 prostatitis cases and 72,799 controls) was utilized as the outcome, while SNPs highly linked with 196 microbial taxa (18 340 people) were chosen as instrumental factors. Random effects, inverse variance weighting, weighted medians, and MR-Egger were used to analyze causal effects. The Cochran's Q test, funnel plot, leave-one-out analysis, and MR-Egger intercept test were all used in the sensitivity analysis.
A causal effect in lowering the incidence of prostatitis is anticipated for five gut microorganisms (Methanobacteria, Methanobacteriaceae, Erysipelatoclostridium, Parasutterella, and Slackia; P < 0.05). Four gut bacteria, including Faecalibacterium, LachnospiraceaeUCG004, Sutterella, and Gastranaerophilales, are predicted to play a causal role in increasing the risk of prostatitis (P < 0.05). There were no discernible estimates of pleiotropy or heterogeneity.
Our investigation established the genetic links between nine gut microorganisms and prostatitis, which may offer fresh perspectives and a theoretical framework for the future prevention and management of prostatitis.
肠道菌群失调可能引发全身炎症，使身体其他部位更易患病。近期研究表明，微生物群可影响前列腺炎以及与前列腺癌相关的前列腺炎症。然而，这种关系是否意味着因果关系仍不明确。我们对两个样本进行了孟德尔随机化研究，以全面揭示肠道微生物群在前列腺炎中潜在的基因因果作用。
以前列腺炎（1859例前列腺炎病例和72799例对照）作为研究结果，选择与196种微生物分类群（18340人）高度相关的单核苷酸多态性（SNP）作为工具变量。采用随机效应、逆方差加权、加权中位数和MR-Egger方法分析因果效应。敏感性分析使用了 Cochr an's Q检验、漏斗图、留一法分析和MR-Egger截距检验。
预计五种肠道微生物（甲烷杆菌、甲烷杆菌科、解脲梭菌属、副萨特氏菌属和斯拉基氏菌属；P<0.05）对降低前列腺炎发病率具有因果效应。预计四种肠道细菌，包括粪杆菌属、毛螺菌科UCG004、萨特氏菌属和嗜气厌氧杆菌目，在增加前列腺炎风险方面起因果作用（P<0.05）。未发现明显的多效性或异质性估计值。
我们的研究确定了九种肠道微生物与前列腺炎之间的基因联系，这可能为未来前列腺炎的预防和管理提供新的视角和理论框架。
