Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
Chem Commun (Camb). 2022 Feb 22;58(16):2706-2709. doi: 10.1039/d1cc07115g.
A novel non-enzymatic electrochemical sensor was constructed to achieve a highly selective and ultrasensitive detection of cholesterol to address the problems related to serious coronary heart disease. The NiVP/Pi-based sensor exhibited ultra-high sensitivity of 5510.18 μA μM cm and 36.8 μA μM cm for 1 nM to 10 μM and 100 μM to 10 mM of cholesterol, respectively, with an ultra-low detection limit of 1 aM, along with superior selectivity for cholesterol when exposed to various interferents such as ascorbic acid, glucose and uric acid. Also, a novel NiVP/Pi-based flexible sensor coated onto Whatman filter paper was developed and displayed superior sensitivity, even with a human blood serum sample at physiological pH.
构建了一种新颖的非酶电化学传感器，以实现对胆固醇的高选择性和超灵敏检测，解决与严重冠心病相关的问题。基于 NiVP/Pi 的传感器表现出超高的灵敏度，对于 1 nM 到 10 μM 和 100 μM 到 10 mM 的胆固醇，分别为 5510.18 μA μM cm 和 36.8 μA μM cm，检测限低至 1 aM，并且在暴露于各种干扰物（如抗坏血酸、葡萄糖和尿酸）时对胆固醇具有优异的选择性。此外，还开发了一种基于 NiVP/Pi 的新型柔性传感器，涂覆在沃特曼滤纸，显示出优异的灵敏度，甚至可以检测生理 pH 值下的人血清样本。
