Nanomaterials Research Group, Physics Division, Pakistan Institute of Nuclear Science and Technology (PINSTECH), Islamabad 44000, Pakistan.
School of Resources and Materials, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China.
Biosensors (Basel). 2022 Nov 1;12(11):955. doi: 10.3390/bios12110955.
The development of a highly sensitive and selective non-enzymatic electrochemical biosensor for precise and accurate determination of multiple disease biomarkers has always been challenging and demanding. The synthesis of novel materials has provided opportunities to fabricate dependable biosensors. In this perspective, we have presented and discussed recent challenges and technological advancements in the development of non-enzymatic cholesterol electrochemical biosensors and recent research trends in the utilization of functional nanomaterials. This review gives an insight into the electrochemically active nanomaterials having potential applications in cholesterol biosensing, including metal/metal oxide, mesoporous metal sulfide, conductive polymers, and carbon materials. Moreover, we have discussed the current strategies for the design of electrode material and key challenges for the construction of an efficient cholesterol biosensor. In addition, we have also described the current issues related to sensitivity and selectivity in cholesterol biosensing.
开发高度灵敏和选择性的非酶电化学生物传感器，以精确和准确地测定多种疾病生物标志物，一直是具有挑战性和要求很高的。新型材料的合成为制造可靠的生物传感器提供了机会。在这方面，我们提出并讨论了非酶胆固醇电化学生物传感器的最新挑战和技术进展，以及功能纳米材料在胆固醇生物传感中的最新研究趋势。本综述深入探讨了在胆固醇生物传感中有应用潜力的电化学活性纳米材料，包括金属/金属氧化物、介孔金属硫化物、导电聚合物和碳材料。此外，我们还讨论了设计电极材料的当前策略以及构建高效胆固醇生物传感器的关键挑战。此外，我们还描述了胆固醇生物传感中与灵敏度和选择性相关的当前问题。
